Topical Antibiotic Prophylaxis for Eyelids
Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases
About this trial
This is an interventional prevention trial for Antibiotic Side Effect
Eligibility Criteria
Inclusion Criteria:
Patients aged 18 and older who are undergoing various eyelid procedures in an office, ambulatory care center, or operating room including but not limited to:
- blepharoplasty (upper and lower lids);
- ectropion repair;
- entropion repair;
- external dacryocystorhinostomy;
- external levator resection;
- eyelid lesion removal and/or biopsy;
- eyelid reconstruction and defect repair including after Mohs surgery;
- fat pad excision (upper and lower lids);
- gold or platinum weight implantation;
- internal levator resection;
- lateral tarsal strip;
- orbital fracture repair requiring periorbital incisions;
- orbitotomy requiring periorbital incisions;
- tarsorrhaphy;
- wedge excision.
- Patients undergoing repeat procedures will also be included.
Exclusion Criteria:
- Patients aged younger than 18 years old who are undergoing the above eyelid procedures in an office, ambulatory care centers, operating rooms;
- patients undergoing chalazion removal;
- patients who have had previous wound infections at the site of the procedure;
- patients with oral or IV antibiotic use within 10 days prior to procedure;
- patients requiring IV antibiotics during the procedure;
- patients with grossly contaminated or inflamed wounds;
- patients with human or animal bites, patients with wounds resulting from trauma
- patients allergic to all study drug options.
Sites / Locations
- University of California, San Francisco
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Topical Antibiotic Ointment
Topical Non-Antibiotic Ointment
Intervention: 200 patients in the antibiotic arm will receive either erythromycin or bacitracin, based on allergies, surgeon preference, and antibiotic availability. If neither antibiotic is obtainable by the patient, bacitracin polymyxin will be prescribed instead. Antibiotic ointment is to be applied to the surgical incision(s) 4 times daily for 1 week.
Intervention: 200 patients in the placebo group will receive mineral oil/petrolatum-based artificial tear ointment to be applied to the surgical incision(s) 4 times daily for 1 week.