Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy
Pain, Mucositis
About this trial
This is an interventional treatment trial for Pain focused on measuring Morphine, Mouthwash, Mucositis, Pain, Cancer, Child, Adolescent
Eligibility Criteria
Inclusion Criteria: Children and adolescents at The Juliane Marie Center at Copenhagen University Hospital (Rigshospitalet, Denmark) or at The University Hospital in Lund (Sweden) Receiving chemotherapy in relation to a cancer disease Pain score of minimum 3 (VAS-scale) at rest for mouth pain in combination with stomatitis of minimum grade 1 (WHO-scale) or a pain score of minimum 5 (VAS-scale) at activity for mouth pain in combination with stomatitis of minimum grade 1 (WHO-scale) Negative pregnancy test, when relevant (judged by physician) Patients and/or parents understand and speak danish (Denmark) / swedish (Sweden) Signed informed consent Exclusion Criteria: Allergic to the investigational medical product Alcohol or drug abuse
Sites / Locations
- The Juliane Marie Center, Copenhagen University Hospital (Rigshospitalet)
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
C group I
C group II
C group III
Morphine mouthwash and placebo i.v.(24 hours) Added on standard analgesic treatment (paracetamol and patient controlled analgesia, morphine)
Placebo mouthwash and morphine i.v.(24 hours) Added on standard analgesic treatment (paracetamol and patient controlled analgesia, morphine)
Placebo mouthwash and placebo i.v. (24 hours) Added on standard analgesic treatment (paracetamol and patient controlled analgesia, morphine)