Transdermal Testosterone Pretreatment in Poor Responders Undergoing IVF
Subfertility
About this trial
This is an interventional treatment trial for Subfertility focused on measuring IVF, poor responder, testosterone
Eligibility Criteria
Inclusion Criteria:
- Advanced maternal age (≥40 years) or any other risk factor for POR
- A previous POR (≤3 oocytes with a conventional stimulation protocol)
- An abnormal ovarian reserve test (i.e. AFC < 5-7 follicles or AMH < 0.5- 1.1 ng/ml)
Exclusion Criteria:
- History of previous ovarian surgery
- Women with endocrine or metabolic disorders
- Women with active cancer disease
- Women with Stage III-IV Endometriosis
- Women with known hypersensitivity or allergy in any of the components of the drug
- Sperm only by ejaculation and not from FNA, TESE or refrigeration
Sites / Locations
- Unit for Human Reproduction, 1st Dept of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Testosterone
Control
Long depot follicular GnRH agonist protocol. On day 21 initiation of ovarian stimulation with recombinant FSH for ICSI. If necessary downregulation will be achieved with additional daily agonist s.c. 10 mg of testosterone gel applied on the external side of the thigh for 21 days starting from the first day of menstruation prior to initiation of ovarian stimulation with rFSH for IVF/ICSI.
Long depot follicular GnRH agonist protocol. On day 21 initiation of ovarian stimulation with recombinant FSH for ICSI. If necessary downregulation will be achieved with additional daily agonist s.c.