Back to results

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Primary Purpose

Breast Cancer; HER2-positive; Metastatic

Status

Recruiting

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Trastuzumab deruxtecan

Placebo

Taxane

Pertuzumab

Trastuzumab

About this trial

This is an interventional treatment trial for Breast Cancer; HER2-positive; Metastatic focused on measuring Breast Neoplasms; Breast Diseases; Trastuzumab; Antineoplastic Agents, Phytogenic; Anti-drug conjugate; Molecular Mechanisms of Pharmacological Action;

Eligibility Criteria

18 Years - 130 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Key Inclusion Criteria:

Patients must be ≥18 years of age
Pathologically documented breast cancer that:
1. is advanced or metastatic
2. is locally assessed and prospectively centrally confirmed as HER2-positive (IHC3+ or ISH+)
3. is documented by local testing as hormone receptor (HR)-positive or HR-negative disease in the metastatic setting
No prior chemotherapy or HER2-targeted therapy for advanced or metastatic breast cancer or only 1 previous line of endocrine therapy in the metastatic setting. Participants who have received chemotherapy or HER2-targeted therapy in the neo-adjuvant or adjuvant setting are eligible if > 6 months from treatment to metastatic diagnosis.
Has protocol-defined adequate organ and bone marrow function
ECOG performance status 0 or 1

Key Exclusion Criteria:

Ineligible for any of the agents on the study.
Any substance abuse or other medical conditions that, in the investigator's opinion, may interfere with subject's participation or study results
Patients with spinal cord compression or clinically active central nervous system metastases. Participants with clinically inactive brain metastases or treated brain metastases that are no longer symptomatic may be included in the study.
Active or prior documented interstitial lung disease (ILD)/pneumonitis or suspected ILD/pneumonitis that cannot be ruled out by imaging at screening
Prior randomization or treatment in a previous trastuzumab deruxtecan study regardless of treatment arm assignment

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Arm Label

Arm A

Arm B

Arm C

Arm Description

Trastuzumab deruxtecan (T-DXd) plus pertuzumab-matching placebo

Trastuzumab deruxtecan (T-DXd) plus pertuzumab

Standard of care (Taxane (paclitaxel or docetaxel), trastuzumab, and pertuzumab)

Outcomes

Primary Outcome Measures

Progression Free Survival (PFS) by Blinded Independent Central Review (BICR) assessment

Defined as time from date of randomisation until the date of objective radiological disease progression according to Blinded Independent Central Review (BICR) using RECIST 1.1 or death by any cause.

Secondary Outcome Measures

Progression Free Survival (PFS) by Investigator assessment

Defined as time from date of randomisation until the date of objective radiological disease progression according to Investigator using RECIST 1.1 or death by any cause.

Overall Survival (OS)

OS is defined as the time from randomisation until the date of death due to any cause.

Objective Response Rate (ORR) by BICR and Investigator assessment

ORR is defined as The proportion of participants who have a complete response (CR) or partial response (PR) based on BICR and investigator assessment using RECIST 1.1.

Duration of Response (DoR) by BICR and Investigator Assessment

DoR is defined as the time from date of first detection of objective response until the date of objective radiological disease progression according to BICR and investigator assessment using RECIST 1.1 or death in the absence of progression.

Time to second progression or death (PFS2) by Investigator assessment

PFS2 is defined as the time from randomisation until the date of tumor progression on next-line treatment (the earliest of the progression event subsequent to first subsequent anticancer therapy after the first progression) or death from any cause; second progression will be defined according to local standard clinical practice.

To assess the effect of T-DXd ± pertuzumab relative to THP in terms of patient-reported pain in participants with HER2 positive, first-line mBC'.

Pain progression: Time to sustained deterioration of European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 Pain Scale. Scores range from 0-100 based on 2 items with responses ranging from 1-4. A lower score would mean better outcome.

To assess patient-reported treatment tolerability

Proportion of participants experiencing treatment related symptoms as measured by selected items from the European Organisation for Research and Treatment of Cancer, general cancer module (EORTC QLQ-C30), score of 1-4. A lower score would mean better outcome.

To assess patient-reported treatment tolerability

Proportion of patients reporting different levels of overall tolerability as measured by the Patient Global Impression of Treatment Tolerability (PGI-TT), score of 0-4. A lower score would mean a better outcome.

To assess patient-reported treatment tolerability

Proportion of participants experiencing treatment related symptoms as measured by selected items from the European Organisation for Research and Treatment of Cancer, breast cancer module (EORTC QLQ-BR45), score of 1-4. A lower score would mean better outcome.

To assess patient-reported treatment tolerability

Proportion of participants experiencing treatment related symptoms as measured by selected items from the Patient-Reported Outcomes- Common Terminology Criteria for Adverse Events (PRO-CTCAE). PRO-CTCAE responses are scored from 0 to 4 (or 0/1 for absent/present). A lower score would mean a better outcome.

To assess patient-reported treatment tolerability

The proportion of participants with maintained or improved physical function while on treatment, based on the EORTC QLQ-C30 Physical Functioning scale. Scores range from 0-100, based on 5 items with responses ranging from 1-4. A higher score would mean a better outcome.

Serum concentration of trastuzumab deruxtecan and pertuzumab

Determination of trastuzumab deruxtecan and pertuzumab concentrations in serum.

Immunogenicity of trastuzumab deruxtecan.

Number and percentage of participants who develop anti-drug antibody (ADA) for trastuzumab deruxtecan.

Safety and tolerability of trastuzumab deruxtecan, alone or with pertuzumab

Number of AEs according to NCI-CTCAE Version 5.0 per each treatment arm

Full Information

NCT ID

NCT04784715

First Posted

February 19, 2021

Last Updated

August 31, 2023

Sponsor

AstraZeneca

Collaborators

Daiichi Sankyo, Inc.

1. Study Identification

Unique Protocol Identification Number

NCT04784715

Brief Title

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Official Title

Phase III Study of Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive, First-line Metastatic Breast Cancer (DESTINY-Breast09)

Study Type

Interventional

2. Study Status

Record Verification Date

August 2023

Overall Recruitment Status

Recruiting

Study Start Date

April 26, 2021 (Actual)

Primary Completion Date

March 28, 2025 (Anticipated)

Study Completion Date

December 30, 2029 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

Collaborators

Daiichi Sankyo, Inc.

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The study will evaluate the efficacy and safety of trastuzumab deruxtecan (also known as T-DXd, DS-8201a), either alone or in combination with pertuzumab, in treating patients with Human epidermal growth factor receptor 2 (HER2)-positive breast cancer as a first line of treatment in the metastatic setting.

Detailed Description

Eligible participants will be those diagnosed with HER2-positive (IHC 3+ or ISH+), metastatic breast cancer, who have received no prior chemotherapy or HER2-targeted therapy for advanced or metastatic breast cancer. The study aims to evaluate the efficacy, and safety of trastuzumab deruxtecan, alone or with pertuzumab, compared with the standard of care treatment (taxane [docetaxel or paclitaxel], trastuzumab and pertuzumab). This study aims to see if trastuzumab deruxtecan allows patients to live longer without the cancer getting worse, or simply to live longer, compared to patients receiving standard of care chemotherapy. This study is also looking to see how the treatment and the cancer affects patients' quality of life.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Breast Cancer; HER2-positive; Metastatic

Keywords

Breast Neoplasms; Breast Diseases; Trastuzumab; Antineoplastic Agents, Phytogenic; Anti-drug conjugate; Molecular Mechanisms of Pharmacological Action;

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Model Description

Study will consist of three arms: Arm A - trastuzumab deruxtecan with pertuzumab-matching placebo Arm B - trastuzumab deruxtecan with pertuzumab Arm C - standard of care (taxane [docetaxel or paclitaxel], trastuzumab and pertuzumab)

Masking

None (Open Label)

Masking Description

This study is open-label with respect to the control arm. Pertuzumab/placebo in the experimental arms will be blinded to the investigator and patients. The study will be "Sponsor-blind". To maintain the integrity of the study, Sponsor personnel directly involved in study conduct will not undertake or have access to efficacy data aggregated by treatment group prior to final data readout for the primary endpoint.

Allocation

Randomized

Enrollment

1134 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Arm A

Arm Type

Experimental

Arm Description

Trastuzumab deruxtecan (T-DXd) plus pertuzumab-matching placebo

Arm Title

Arm B

Arm Type

Experimental

Arm Description

Trastuzumab deruxtecan (T-DXd) plus pertuzumab

Arm Title

Arm C

Arm Type

Active Comparator

Arm Description

Standard of care (Taxane (paclitaxel or docetaxel), trastuzumab, and pertuzumab)

Intervention Type

Drug

Intervention Name(s)

Trastuzumab deruxtecan

Other Intervention Name(s)

DS-8201a; T-DXd

Intervention Description

Administered by intravenous infusion

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Administered by intravenous infusion

Intervention Type

Drug

Intervention Name(s)

Taxane

Intervention Description

Investigator's choice of docetaxel or paclitaxel administered by intravenous infusion

Intervention Type

Drug

Intervention Name(s)

Pertuzumab

Intervention Description

Administered by intravenous infusion

Intervention Type

Drug

Intervention Name(s)

Trastuzumab

Intervention Description

Administered by intravenous infusion

Primary Outcome Measure Information:

Title

Progression Free Survival (PFS) by Blinded Independent Central Review (BICR) assessment

Description

Defined as time from date of randomisation until the date of objective radiological disease progression according to Blinded Independent Central Review (BICR) using RECIST 1.1 or death by any cause.

Time Frame

Until progression or death, assessed up to approximately 60 months

Secondary Outcome Measure Information:

Title

Progression Free Survival (PFS) by Investigator assessment

Description

Defined as time from date of randomisation until the date of objective radiological disease progression according to Investigator using RECIST 1.1 or death by any cause.

Time Frame

Until progression or death, assessed up to approximately 60 months

Title

Overall Survival (OS)

Description

OS is defined as the time from randomisation until the date of death due to any cause.

Time Frame

Until death, assessed up to approximately 104 months

Title

Objective Response Rate (ORR) by BICR and Investigator assessment

Description

ORR is defined as The proportion of participants who have a complete response (CR) or partial response (PR) based on BICR and investigator assessment using RECIST 1.1.

Time Frame

Until progression or death (in the absence of progression), assessed up to approximately 60 months

Title

Duration of Response (DoR) by BICR and Investigator Assessment

Description

Time Frame

Until progression or death (in the absence of progression), assessed up to approximately 60 months

Title

Time to second progression or death (PFS2) by Investigator assessment

Description

Time Frame

Assessed up to approximately 104 months

Title

To assess the effect of T-DXd ± pertuzumab relative to THP in terms of patient-reported pain in participants with HER2 positive, first-line mBC'.

Description

Time Frame

Assessed up to approximately 60 months

Title

To assess patient-reported treatment tolerability

Description

Time Frame

Assessed up to approximately 60 months

Title

To assess patient-reported treatment tolerability

Description

Time Frame

Assessed up to approximately 60 months

Title

To assess patient-reported treatment tolerability

Description

Time Frame

Assessed up to approximately 60 months

Title

To assess patient-reported treatment tolerability

Description

Time Frame

Assessed up to approximately 60 months

Title

To assess patient-reported treatment tolerability

Description

Time Frame

Assessed up to approximately 60 months

Title

Serum concentration of trastuzumab deruxtecan and pertuzumab

Description

Determination of trastuzumab deruxtecan and pertuzumab concentrations in serum.

Time Frame

Up to Cycle 6, approximately Week 18; each cycle is 21 days

Title

Immunogenicity of trastuzumab deruxtecan.

Description

Number and percentage of participants who develop anti-drug antibody (ADA) for trastuzumab deruxtecan.

Time Frame

Up to follow-up period, approximately 60 months

Title

Safety and tolerability of trastuzumab deruxtecan, alone or with pertuzumab

Description

Number of AEs according to NCI-CTCAE Version 5.0 per each treatment arm

Time Frame

Assessed up to approximately 60 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

130 Years

Accepts Healthy Volunteers

Eligibility Criteria

Key Inclusion Criteria: Patients must be ≥18 years of age Pathologically documented breast cancer that: is advanced or metastatic is locally assessed and prospectively centrally confirmed as HER2-positive (IHC3+ or ISH+) is documented by local testing as hormone receptor (HR)-positive or HR-negative disease in the metastatic setting No prior chemotherapy or HER2-targeted therapy for advanced or metastatic breast cancer or only 1 previous line of endocrine therapy in the metastatic setting. Participants who have received chemotherapy or HER2-targeted therapy in the neo-adjuvant or adjuvant setting are eligible if > 6 months from treatment to metastatic diagnosis. Has protocol-defined adequate organ and bone marrow function ECOG performance status 0 or 1 Key Exclusion Criteria: Ineligible for any of the agents on the study. Any substance abuse or other medical conditions that, in the investigator's opinion, may interfere with subject's participation or study results Patients with spinal cord compression or clinically active central nervous system metastases. Participants with clinically inactive brain metastases or treated brain metastases that are no longer symptomatic may be included in the study. Active or prior documented interstitial lung disease (ILD)/pneumonitis or suspected ILD/pneumonitis that cannot be ruled out by imaging at screening Prior randomization or treatment in a previous trastuzumab deruxtecan study regardless of treatment arm assignment

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

AstraZeneca Clinical Study Information Center

Phone

1-877-240-9479

information.center@astrazeneca.com

First Name & Middle Initial & Last Name or Official Title & Degree

AZ Breast Cancer Study Navigators

Phone

+1-877-400-4656

AstraZeneca@CareboxHealth.com

Facility Information:

Facility Name

Research Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85054

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85711

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85715

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Springdale

State/Province

Arkansas

ZIP/Postal Code

72762

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Duarte

State/Province

California

ZIP/Postal Code

91010

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Glendale

State/Province

California

ZIP/Postal Code

91204

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Glendale

State/Province

California

ZIP/Postal Code

91206

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92123

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Longmont

State/Province

Colorado

ZIP/Postal Code

80501

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33901

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33176

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Port Richey

State/Province

Florida

ZIP/Postal Code

34655

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Palm Bay

State/Province

Florida

ZIP/Postal Code

32909

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Plantation

State/Province

Florida

ZIP/Postal Code

33324

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Petersburg

State/Province

Florida

ZIP/Postal Code

33705

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30318

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Arlington Heights

State/Province

Illinois

ZIP/Postal Code

60005

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40241

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70817

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Silver Spring

State/Province

Maryland

ZIP/Postal Code

20904

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02215

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55404

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39213

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68114

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89128

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

East Brunswick

State/Province

New Jersey

ZIP/Postal Code

08816

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Morristown

State/Province

New Jersey

ZIP/Postal Code

07960

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Summit

State/Province

New Jersey

ZIP/Postal Code

07901

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Albany

State/Province

New York

ZIP/Postal Code

12206

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10469

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Hyde Park

State/Province

New York

ZIP/Postal Code

11042

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New York

State/Province

New York

ZIP/Postal Code

10028

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New York

State/Province

New York

ZIP/Postal Code

10065

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Port Jefferson Station

State/Province

New York

ZIP/Postal Code

11776

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58102

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Delaware

State/Province

Ohio

ZIP/Postal Code

43015

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Portland

State/Province

Oregon

ZIP/Postal Code

97223

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

York

State/Province

Pennsylvania

ZIP/Postal Code

17403

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57104

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37404

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Germantown

State/Province

Tennessee

ZIP/Postal Code

38138

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37203

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Austin

State/Province

Texas

ZIP/Postal Code

78731

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75203

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75230

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75246

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Denton

State/Province

Texas

ZIP/Postal Code

76201

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77090

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78240

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenandoah

State/Province

Texas

ZIP/Postal Code

77380

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tyler

State/Province

Texas

ZIP/Postal Code

75702

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84106

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23502

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Roanoke

State/Province

Virginia

ZIP/Postal Code

24014

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caba

ZIP/Postal Code

1414

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caba

ZIP/Postal Code

C1012AAR

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caba

ZIP/Postal Code

C1118AAT

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Capital Federal

ZIP/Postal Code

C1417DTB

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cipolletti

ZIP/Postal Code

8234

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ciudad Autonoma De Buenos Aire

ZIP/Postal Code

C1125ABD

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ciudad de Buenos Aires

ZIP/Postal Code

1280

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

La Plata

ZIP/Postal Code

1900

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mar del Plata

ZIP/Postal Code

7600

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rosario

ZIP/Postal Code

S2000DEJ

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rosario

ZIP/Postal Code

S2002KDS

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Salvador de Jujuy

ZIP/Postal Code

4600

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Innsbruck

ZIP/Postal Code

6020

Country

Austria

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Wien

ZIP/Postal Code

1090

Country

Austria

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Brussels

ZIP/Postal Code

1160

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bruxelles

ZIP/Postal Code

1200

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Charleroi

ZIP/Postal Code

6000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Edegem

ZIP/Postal Code

2650

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gent

ZIP/Postal Code

9000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Liège

ZIP/Postal Code

4000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Namur

ZIP/Postal Code

5000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barretos

ZIP/Postal Code

14784-400

Country

Brazil

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Brasília

ZIP/Postal Code

70200-730

Country

Brazil

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Florianópolis

ZIP/Postal Code

88034-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Goiânia

ZIP/Postal Code

74000-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Londrina

ZIP/Postal Code

86015-520

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Natal

ZIP/Postal Code

59075-740

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

90035-003

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ribeirão Preto

ZIP/Postal Code

14015-130

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sorocaba

ZIP/Postal Code

18030-005

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

São Paulo

ZIP/Postal Code

03102-002

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vitoria

ZIP/Postal Code

29043-260

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T2N 4N2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3H 2Y9

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barrie

State/Province

Ontario

ZIP/Postal Code

L4M 6M2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kitchener

State/Province

Ontario

ZIP/Postal Code

N2G 1G3

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Newmarket

State/Province

Ontario

ZIP/Postal Code

L3Y 2P9

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

North York

State/Province

Ontario

ZIP/Postal Code

M2K 1E1

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5G 1X5

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H1T 2M4

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H2X 3E4

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1M5

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4A 3J1

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ste-Foy

State/Province

Quebec

ZIP/Postal Code

G1V 4G2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7N 4H4

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100039

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100044

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100191

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changchun

ZIP/Postal Code

130021

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

410008

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

410013

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610041

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chongqing

ZIP/Postal Code

400016

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chongqing

ZIP/Postal Code

400030

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chongqing

ZIP/Postal Code

400038

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dalian

ZIP/Postal Code

116011

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510060

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510080

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510120

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guiyang

ZIP/Postal Code

550004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hangzhou

ZIP/Postal Code

310003

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hangzhou

ZIP/Postal Code

310022

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Harbin

ZIP/Postal Code

150049

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hefei

ZIP/Postal Code

230022

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Kunming

ZIP/Postal Code

650118

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanchang

ZIP/Postal Code

330009

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210008

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210029

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanning

ZIP/Postal Code

530021

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Qingdao

ZIP/Postal Code

266100

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200025

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200032

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenyang

ZIP/Postal Code

110001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenzhen

ZIP/Postal Code

518036

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tianjin

ZIP/Postal Code

300060

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wu Han

ZIP/Postal Code

430060

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wuhan

ZIP/Postal Code

430022

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wuhan

ZIP/Postal Code

430030

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xi'an

ZIP/Postal Code

710004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xi'an

ZIP/Postal Code

710061

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yinchuan

ZIP/Postal Code

750004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zhengzhou

ZIP/Postal Code

450008

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aalborg

ZIP/Postal Code

9000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Copenhagen O

ZIP/Postal Code

2100

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Odense C

ZIP/Postal Code

5000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sønderborg

ZIP/Postal Code

6400

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vejle

ZIP/Postal Code

7100

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Avignon

ZIP/Postal Code

84000

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Besancon

ZIP/Postal Code

25000

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bordeaux

ZIP/Postal Code

33030

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caen Cedex

ZIP/Postal Code

14076

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Le Mans

ZIP/Postal Code

72000

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montpellier

ZIP/Postal Code

34070

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montpellier

ZIP/Postal Code

34298

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nice Cedex 2

ZIP/Postal Code

06189

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Paris

ZIP/Postal Code

75005

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pierre Benite Cedex

ZIP/Postal Code

69495

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rennes

ZIP/Postal Code

35042

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Cloud

ZIP/Postal Code

92210

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Herblain

ZIP/Postal Code

44805

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toulouse Cedex 9

ZIP/Postal Code

31059

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vandoeuvre les Nancy

ZIP/Postal Code

54519

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

10117

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

13125

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bonn

ZIP/Postal Code

53111

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dresden

ZIP/Postal Code

1307

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Erlangen

ZIP/Postal Code

91054

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Essen

ZIP/Postal Code

45136

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Essen

ZIP/Postal Code

45147

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Frankfurt am Main

ZIP/Postal Code

60431

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Frankfurt

ZIP/Postal Code

60590

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Freiburg

ZIP/Postal Code

79110

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

20357

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Heidelberg

ZIP/Postal Code

69120

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kiel

ZIP/Postal Code

24105

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Koblenz Am Rhein

ZIP/Postal Code

56068

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leipzig

ZIP/Postal Code

04103

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mainz Am Rhein

ZIP/Postal Code

55131

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mannheim

ZIP/Postal Code

68167

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Muenster

ZIP/Postal Code

48149

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Neu-Isenburg

ZIP/Postal Code

63263

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Paderborn

ZIP/Postal Code

33161

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rostock

ZIP/Postal Code

18059

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Troisdorf

ZIP/Postal Code

53840

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1062

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1083

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1115

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1122

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1145

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Győr

ZIP/Postal Code

9024

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kecskemét

ZIP/Postal Code

6000

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Miskolc

ZIP/Postal Code

3526

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nyíregyháza

ZIP/Postal Code

4400

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Szolnok

ZIP/Postal Code

5004

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ahmedabad

ZIP/Postal Code

380060

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bangalore

ZIP/Postal Code

560027

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Belagavi

ZIP/Postal Code

590010

Country

India

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bengaluru

ZIP/Postal Code

560099

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Calicut

ZIP/Postal Code

673601

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gurgaon

ZIP/Postal Code

122001

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mysuru

ZIP/Postal Code

570017

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nashik

ZIP/Postal Code

422009

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nashik

ZIP/Postal Code

422011

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110075

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110085

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Haifa

ZIP/Postal Code

31096

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jerusalem

ZIP/Postal Code

9112001

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Petah Tikva

ZIP/Postal Code

4941492

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ramat Gan

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tel-Aviv

ZIP/Postal Code

64239

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aviano

ZIP/Postal Code

33081

Country

Italy

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bergamo

ZIP/Postal Code

24127

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Candiolo

ZIP/Postal Code

10060

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Genova

ZIP/Postal Code

16132

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Livorno

ZIP/Postal Code

57100

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Milan

ZIP/Postal Code

20141

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Napoli

ZIP/Postal Code

80131

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Padova

ZIP/Postal Code

35128

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rozzano

ZIP/Postal Code

20089

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Udine

ZIP/Postal Code

33100

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Akashi-shi

ZIP/Postal Code

673-8558

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aomori-shi

ZIP/Postal Code

030-8553

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bunkyo-ku

ZIP/Postal Code

113-8431

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chiba-shi

ZIP/Postal Code

260-8717

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

104-0045

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fukushima-shi

ZIP/Postal Code

960-1295

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hidaka-shi

ZIP/Postal Code

350-1298

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hiroshima-shi

ZIP/Postal Code

730-8518

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hiroshima-shi

ZIP/Postal Code

734-8551

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Isehara-shi

ZIP/Postal Code

259-1193

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kagoshima-shi

ZIP/Postal Code

892-0833

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kawasaki-shi

ZIP/Postal Code

216-8511

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kobe-shi

ZIP/Postal Code

650-0047

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Koto-ku

ZIP/Postal Code

135-8550

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kurume-shi

ZIP/Postal Code

830-0011

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kyoto-shi

ZIP/Postal Code

606-8507

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Matsuyama-shi

ZIP/Postal Code

791-0280

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagoya-shi

ZIP/Postal Code

464-8681

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagoya-shi

ZIP/Postal Code

467-0001

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Niigata-shi

ZIP/Postal Code

951-8566

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nishinomiya-shi

ZIP/Postal Code

663-8501

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Okayama

ZIP/Postal Code

700-8558

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Osaka-shi

ZIP/Postal Code

541-8567

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ota-shi

ZIP/Postal Code

373-8550

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sapporo-shi

ZIP/Postal Code

003-0804

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sendai-shi

ZIP/Postal Code

980-8574

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shinagawa-ku

ZIP/Postal Code

142-8666

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shinjuku-ku

ZIP/Postal Code

160-0023

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shinjuku-ku

ZIP/Postal Code

162-8655

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shizuoka

ZIP/Postal Code

420-8527

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tsu-shi

ZIP/Postal Code

514-8507

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yokohama-shi

ZIP/Postal Code

241-8515

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cheonan-si

ZIP/Postal Code

31151

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

41404

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Goyang-si

ZIP/Postal Code

410-769

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

03080

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

05505

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

06273

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

06351

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

06591

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

08308

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

120-752

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Acapulco

ZIP/Postal Code

39670

Country

Mexico

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Alc. Cuauhtémoc

ZIP/Postal Code

06700

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Del. Cuauhtemoc

ZIP/Postal Code

06700

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Estado de México

ZIP/Postal Code

50080

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara Jalisco

ZIP/Postal Code

44280

Country

Mexico

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44680

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Metepec

ZIP/Postal Code

52140

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mexico

ZIP/Postal Code

6760

Country

Mexico

Individual Site Status

Withdrawn

Facility Name

Research Site

City

MEX

ZIP/Postal Code

14080

Country

Mexico

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Nuevo Leon

ZIP/Postal Code

66278

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Arequipa

ZIP/Postal Code

AREQUIPA01

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

15033

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

15036

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

L27

Country

Peru

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 29

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 34

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baguio City

ZIP/Postal Code

2600

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cebu City

ZIP/Postal Code

6000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Davao City

ZIP/Postal Code

8000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iloilo City

ZIP/Postal Code

5000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Manila

ZIP/Postal Code

1000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quezon City

ZIP/Postal Code

1112

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Juan

ZIP/Postal Code

1500

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bucharest

ZIP/Postal Code

011461

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bucuresti

ZIP/Postal Code

011171

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Cluj-Napoca

ZIP/Postal Code

400015

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Cluj-Napoca

ZIP/Postal Code

400015

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Constanta

ZIP/Postal Code

900591

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Floresti

ZIP/Postal Code

407280

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iasi

ZIP/Postal Code

700483

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Timisoara

ZIP/Postal Code

300239

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

111123

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

121205

Country

Russian Federation

Individual Site Status

Completed

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

129090

Country

Russian Federation

Individual Site Status

Terminated

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

143442

Country

Russian Federation

Individual Site Status

Recruiting

Facility Name

Research Site

City

Omsk

ZIP/Postal Code

644033

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Saint Petersburg

ZIP/Postal Code

190020

Country

Russian Federation

Individual Site Status

Suspended

Facility Name

Research Site

City

Saint Petersburg

ZIP/Postal Code

197758

Country

Russian Federation

Individual Site Status

Suspended

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

197758

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Yaroslavl

ZIP/Postal Code

150054

Country

Russian Federation

Individual Site Status

Suspended

Facility Name

Research Site

City

Dammam

ZIP/Postal Code

31444

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jeddah

ZIP/Postal Code

22384

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jeddah

ZIP/Postal Code

23214

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Makkah

ZIP/Postal Code

24246

Country

Saudi Arabia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

11211

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

11426

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

11525

Country

Saudi Arabia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Riyadh

ZIP/Postal Code

12987

Country

Saudi Arabia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Cape Town

ZIP/Postal Code

7570

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cape Town

ZIP/Postal Code

7925

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

George

ZIP/Postal Code

6529

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Johannesburg

ZIP/Postal Code

2196

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Parktown

ZIP/Postal Code

2193

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Port Elizabeth

ZIP/Postal Code

6045

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pretoria

ZIP/Postal Code

0081

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rondebosch

ZIP/Postal Code

7700

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Soweto

ZIP/Postal Code

2013

Country

South Africa

Individual Site Status

Recruiting

Facility Name

Research Site

City

Alicante

ZIP/Postal Code

03010

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08028

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08036

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

8035

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28005

Country

Spain

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28041

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28046

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Majadahonda

ZIP/Postal Code

28222

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Sebastian

ZIP/Postal Code

20014

Country

Spain

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Sevilla

ZIP/Postal Code

41009

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 45

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stockholm

ZIP/Postal Code

118 83

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Uppsala

ZIP/Postal Code

75185

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Växjö

ZIP/Postal Code

35185

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Örebro

ZIP/Postal Code

701 85

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taichung

ZIP/Postal Code

40443

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tainan

ZIP/Postal Code

70403

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

100

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

10449

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

11217

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

235

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taoyuan

ZIP/Postal Code

333

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Adana

ZIP/Postal Code

01330

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ankara

ZIP/Postal Code

06520

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ankara

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Karsiyaka

ZIP/Postal Code

35575

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Malatya

ZIP/Postal Code

44280

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Samsun

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Buckhurst Hill

ZIP/Postal Code

IG9 5HX

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Edinburgh

ZIP/Postal Code

EH4 2XU

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guildford

ZIP/Postal Code

GU2 7WG

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

London

ZIP/Postal Code

NW1 2PG

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

London

ZIP/Postal Code

NW3 2QG

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Maidstone

ZIP/Postal Code

ME16 9QQ

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Manchester

ZIP/Postal Code

M20 4BX

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Swansea

ZIP/Postal Code

SA2 8QA

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taunton

ZIP/Postal Code

TA1 5DA

Country

United Kingdom

Individual Site Status

Recruiting

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

IPD Sharing Time Frame

AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

IPD Sharing Access Criteria

When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.

IPD Sharing URL

https://astrazenecagroup-dt.pharmacm.com/DT/Home

Links:

URL

https://breastcancerstudylocator.com/

Description

BreastCancerStudyLocator.com

URL

http://CTRinfo@dsi.com

Description

Daiichi Sankyo Contact for Clinical Trial Information Phone: 908-992-6400

Learn more about this trial

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

We'll reach out to this number within 24 hrs

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Breast Cancer; HER2-positive; Metastatic

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial