Treating Postictal Symptoms Using Ibuprofen and Nifedipine
Epilepsy, Epilepsies, Partial
About this trial
This is an interventional treatment trial for Epilepsy focused on measuring Postictal, Blood flow
Eligibility Criteria
Inclusion Criteria:
- age > 16 yrs, frequent seizures (>1 per week) and cognitive ability sufficient to complete neuropsychological testing.
Exclusion Criteria:
- multiple seizure onset zones, contraindications to CT or MR imaging, any contraindication to ibuprofen or nifedipine, as well as current or recent (< 2 months) exposure COX-2 inhibitor or calcium channel blocker.
Sites / Locations
- Foothills Medical CentreRecruiting
- South Health CampusRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Experimental
Experimental
Placebo
Ibuprofen
Nifedipine
Patients will receive placebo for at least five days prior to the first blood flow study. They will continue to receive placebo until the baseline study is obtained after the postictal study has been completed.
Patients will receive ibuprofen 400 mg by mouth three times a day (po tid) for at least five days prior to the first blood flow study. They will continue to receive ibuprofen until the baseline study is obtained after the postictal study has been completed.
Patients will receive nifedipine 10 mg po tid for 2 days, then 20 mg po tid, thereafter for at least five days prior to the first blood flow study. They will continue to receive nifedipine until the baseline study is obtained after the postictal study has been completed.