Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
Borderline Personality Disorder
About this trial
This is an interventional treatment trial for Borderline Personality Disorder focused on measuring suicide, self-mutilation, fluoxetine, placebo, dialectical behavior therapy, supportive therapy
Eligibility Criteria
Inclusion Criteria:
- Meets criteria for diagnosis of borderline personality disorder
- History of at least one suicide attempt or self-mutilation episode 12 months prior to study entry
- Experiences continued urges to self-mutilate or attempt suicide
- Stable living situation
- Use of effective birth control if sexually active
- Clinically stable enough to tolerate placebo condition
- Not participating in other forms of treatment during the study
Exclusion Criteria:
- Any current organic mental syndromes, lifetime schizophrenic or bipolar disorders, psychotic disorders, or mental retardation
- Inability to complete psychiatric interview due to lack of cooperation or lack of comprehension
- Unable to tolerate fluoxetine or DBT
- Currently receiving treatment for an acute medical illness or other debilitating problem, including substance abuse or anorexia nervosa
- History of major depression lasting more than 3 months
- Current Hamilton depression score above 22 and not receiving treatment
- Pregnant or breastfeeding
Sites / Locations
- New York State Psychiatric Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Active Comparator
Dialectical Behavior Therapy Fluoxetine
Dialectical Behavior Therapy placebo
Supportive therapy Fluoxetine
Supportive therapy placebo
Dialectal behavior therapy (DBT) is a form of Cognitive behavior therapy (CBT) targeting suicidal and non-suicidal self injury in borderline personality disorder and is delivered over a 12 month period,and fluoxetine, a selective serotonin reuptake inhibitor (SSRI) that is given in standard dosing 20, 40, 60, 80 mg for 12 months.
Dialectal behavior therapy and placebo Dialectal behavior therapy (DBT) is a form of Cognitive behavior therapy targeting suicidal and non-suicidal self injury in borderline personality disorder and is delivered over a 12 month period, and placebo for fluoxetine, an SSRI that is given in standard dosing 20, 40, 60, 80 mg for 12 months.
Supportive psychotherapy and fluoxetine Supportive therapy is a manualized psychotherapy aimed at strengthening coping skills and is delivered over a 12 month period, and fluoxetine, an SSRI that is given in standard dosing 20, 40, 60, 80 mg for 12 months.
Supportive psychotherapy and placebo See above for descriptions.