Treatment of Mid-Life-Related Mood Disorders

INCLUSION CRITERIA: Subjects for this study will meet the following criteria: A current episode of minor (meeting 3-4 criterion symptoms) or major depression of moderate severity or less on the SCID severity scale for depression and not meeting DSM-IV criteria symptom #9 (suicide) as determined by the administration of the minor depression module of the SADS-L and the Structured Clinical Interview for DSM-IV. Additionally, to ensure that subjects meet a minimum threshold for severity of depression, subjects will have scores greater than or equal to 10 on either the Beck Depression Inventory (BDI) or the Center for Epidemiologic Studies - Depression (CES-D) Scale during at least three of the four clinic visits during the two month screening phase. Subjects will be excluded if they meet any of the following criteria: major depression of greater than moderate severity, DSM-IV criteria #9 (suicide), or anyone requiring immediate treatment after clinical assessment, functional impairment ratings of five or six for more than seven consecutive days on daily ratings; Age 40-65; No prior hormonal therapy for the treatment of menopause/andropause-related mood or physical symptoms within the last six months; In good medical health. EXCLUSION CRITERIA: The following conditions will constitute contradictions to treatment with DHEA and will preclude a subject's participation in this protocol: Positive (threshold) response to SCID major depression section item #9, suicidal ideation; Anyone requiring immediate treatment after clinical assessment; Severity ratings greater than moderate on the SCID; Functional impairment ratings of five or six for more than seven consecutive days on daily ratings Current treatment with antidepressant medications Prostate nodules or cancer Moderate symptoms of benign prostatic hypertrophy such as hesitancy, urgency, frequent voiding and feeling of incomplete voiding History of ischemic cardiac disease Renal disease Hepatic dysfunction Women with a history of carcinoma of the breast, or any women with a family history of the following: premenopausal breast cancer or bilateral breast cancer in a first degree relative; multiple family members (greater than three relatives) with postmenopausal breast cancer Women with a history of uterine cancer Patients with a known hypersensitivity to DHEA or other androgens Pregnant women