Treatment of Orthostatic Intolerance
Tachycardia, Chronic Orthostatic Intolerance
About this trial
This is an interventional treatment trial for Tachycardia focused on measuring tachycardia, sinus tachycardia, postural tachycardia syndrome (POTS)
Eligibility Criteria
Inclusion Criteria: Chronic symptoms (> 6 months) with standing upright Exclusion Criteria: Obvious cause of hypovolemia or drugs that could worsen tachycardia Chronic severe medical conditions such as cancer or ischemic heart disease
Sites / Locations
- Vanderbilt University Autonomic Dysfunction Center
Arms of the Study
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Arm 20
Experimental
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Experimental
Placebo Comparator
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Experimental
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Abdominal Binder
Acetazolamide
Atomoxetine
NO Drug
Clonidine
Entacapone
Indomethacin
Isosorbide Dinitrate
Mecamylamine
Memantine
Melatonin
Midodrine
Modafinil
Octreotide
Placebo (lactose tablet)
Propranolol
Sertraline
Normal Saline (0.9%) 1 liter
Drinking Water
Dead Space Breathing Device
Abdominal binder with inflatable pressure over abdomen