Treatment of Patients With Periorbital Hyperpigmentation
Periorbital Hypermelanosis
About this trial
This is an interventional treatment trial for Periorbital Hypermelanosis focused on measuring Periorbital hypermelanosis, Carboxy therapy, Microneedling, Topical Glutathione
Eligibility Criteria
Inclusion Criteria:
- Patients with Periorbital hyperpigmentation
Exclusion Criteria:
- Pregnancy and lactation .
- Allergy, hypersensitivity to the formulations to be used in the study.
- Any other cutaneous or systemic disease.
- Patient who had taken any other treatment (laser, dermabrasion) on the affected region performed less than 6 months prior to the beginning of the study.
Sites / Locations
- Faculty of Medicine, Sohag University
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Rt Eye
Lt Eye
The right eye of the patients received carboxy therapy for 6 sessions every 2 weeks. The used device is locally manufactured by a national company for esthetic and dermatological devices. Carbon dioxide gas was subcutaneously injected at the lateral one-third of each eye lid (5 cc gas in each puff according to standardized flowmetry) using insulin syringe. Compression of the injected area will be avoided to prevent rapid leakage of the gas.
The left eye of the same patients received microneedling with topical glutathione for 6 sessions every 2 weeks. Microneedling was done with Derma pen which is automatic and rechargeable device (vibrating frequency : 6500-10000 r/m , vibration speed level 5 , model :Ultima A6 , company : Dr ,pen and country : Korea). Needle length is adjustable from 0.25 mm to 0,5 mm.Needles number : 36 .Then, Patient was subjected to topical glutathione about 0.25 ml (vial : 600mg/5ml).