Treatment of Refractory Status Epilepticus
Status Epilepticus
About this trial
This is an interventional treatment trial for Status Epilepticus focused on measuring Refractory status epilepticus,, coma-induction,, treatment,, propofol,, barbiturates,, efficacy,, safety.
Eligibility Criteria
Inclusion Criteria: Patients with refractory status epilepticus not due to cerebral anoxia, needing coma induction for clinical management. Exclusion Criteria: Age < 16 years old. Known pregnancy. Cerebral anoxia as SE etiology. Epilepsia partialis continua (simple partial SE). Known intolerance to the study drugs. Known mitochondrial disorder, hyperlipidemia, or significant rhabdomyolysis.
Sites / Locations
- Massachusetts General Hospital
- Brigham and Women's Hospital
- Inselspital
- CHUV
- Hôpitaux Universitaires de Genève
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
1
2
propofol, 2mg/kg as bolus, then titrated up to EEG burst-suppression as a continuous infusion; no maximum doses defined
thiopental/pentobarbital, 2mg/kg as bolus, then titrated up to EEG burst-suppression as a continuous infusion; no maximum doses defined