Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
Osteoporosis, Spinal Cord Injuries
About this trial
This is an interventional prevention trial for Osteoporosis focused on measuring Osteoporosis, Spinal Cord Injuries, Dual Energy X-ray Absorptiometry, Denosumab, Romosozumab
Eligibility Criteria
Inclusion Criteria:
- Traumatic motor-complete SCI C4-L2 (AIS grade A & B);
- Duration of SCI less than 6 months;
- Males and females (premenopausal) between the ages of 18 and 50 years old; and a safe range of BMD right above the knee as determined by study staff review;
Exclusion Criteria:
- Active and/or history of coronary heart disease or stroke;
- Bone cancer;
- Long-bone fracture of the leg within the past year;
- History of prior bone disease (for example, Paget's hyperparathyroidism, osteoporosis, etc.);
- Postmenopausal women;
- Men with known low functioning tests before SCI;
- Drugs geared toward increasing BMD longer than a six month duration after SCI;
- As determined by study staff review of my medication history of glucocorticoid administration longer than three months duration within the last year
- Abnormalities of my endocrine glands such as hyperthyroidism, Cushing's disease or syndrome, etc.;
- Severe underlying chronic disease (for example chronic obstructive pulmonary disease (COPD), end-stage heart disease, chronic renal failure);
- Heterotopic ossification (HO) of the distal femur (the knee end of the thigh bone). HO is a condition where bone tissue forms outside of the skeleton. If HO is found in any other area than the distal femur it will not prevent my participation in the study.;
- History of chronic alcohol abuse;
- Diagnosis of hypercalcemia (high levels of calcium in the blood);
- Pregnancy;
- As determined by study staff review of my medications a bisphosphonate for heterotopic ossification (HO), or other medications to treat osteoporosis other than calcium and vitamin D;
- Current diagnosis of cancer or history of cancer;
- As determined by study staff review of my medications, prescribed moderate or high dose corticosteroids (>40 mg/d prednisone or an equivalent dose of other corticosteroid medication) for longer than one week, not including drug administered to preserve neurological function at the time of acute SCI; and
- Life expectancy less than 5 years.
Sites / Locations
- Kessler Institute for RehabilitationRecruiting
- James J. Peters VA Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Romosozumab Baseline to Month 11 followed by Denosumab Month 12 to Month 24
Denosumab Baseline to Month 24
Of the forty (40) individuals with subacute spinal cord injury (SCI) enrolled in this study, twenty (20) participants will be randomly selected to receive romosozumab (210mg SQ) once a month for 12 months. After 12 months the same twenty (20) individuals will receive denosumab (60mg SQ) at month 12 and 18.
Of the forty (40) individuals with subacute spinal cord injury (SCI) enrolled in this study, twenty (20) participants will be randomly selected to receive denosumab (60 mg SQ) at baseline and 6, 12, and 18 months.