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Trial to Assess Chelation Therapy (TACT)

Primary Purpose

Coronary Artery Disease

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
EDTA
EDTA Placebo
High Dose Vitamin
High Dose Vitamin Placebo
Sponsored by
Mt. Sinai Medical Center, Miami
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Coronary Artery Disease

Eligibility Criteria

50 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria for Participants: Heart attack at least 6 weeks prior to study start Exclusion Criteria for Participants: Serum creatinie level greater than 2.0 mg/dL Platelet count less than 100,000/µL Blood pressure greater than 160/100 Chelation therapy within 5 years prior to study start History of allergic reactions to EDTA or any of the therapy's components Coronary or carotid revascularization procedures within 6 months prior to study start or a scheduled revascularization Cigarette smoking within 3 months prior to study start Childbearing potential History of liver disease Active heart failure or heart failure hospitalization within 6 months. Diagnoses of additional medical conditions that could otherwise limit patient survival Inability to tolerate 500-mL infusions weekly.

Sites / Locations

  • Central Arkansas Veterans Healthcare System
  • University of Arkansas for Medical Sciences
  • Mt Holistic Health Center
  • Patrick A. Golden
  • Scripps Center for Integrative Medicine
  • Phoenix Wellness Group
  • Aurora Denver Cardiology Associates
  • The Blend Institute
  • Wellness Works
  • Innovative Research of West Florida
  • White-Wilson Medical Center
  • Hyperbaric Medicine Inc.
  • Tru Med
  • Mount Sinai Medical Center
  • Baptist Cardiac & Vascular Institute
  • Tri-Health Alternative Medical Center
  • Heart and Vascular Center for Research, Inc.
  • Florida Cardiovascular Institute
  • Life Family Practice Center for Complementary and Alternative Medicine
  • Florida Medical Clinic, P.A. Clinical Research Division
  • Emory University School of Medicine
  • Full Circle Medical Center
  • Crossroads Healing Arts LLC
  • Integrative Medical Center at Schneck Medical Center
  • Northwest Indiana Cardiovascular Physicians Inc.
  • Kansas University Medical Center
  • The Center for the Improvement of Functioning International
  • Complementary Medical Services
  • Maine Integrative Wellness
  • Johns Hopkins Bayview Medical Center
  • Marino Center for Progressive Health
  • Henry Ford Health System Preventative Cardiology Clay Ford Center for Athletic Medicine
  • The Preventive Medicine Center
  • Born Preventive Health Care Clinic
  • Parchment Family Practice
  • Berman Center for Outcomes and Clinical Research
  • Mayo Clinic and Foundation Cardiovascular Health Clinic
  • University of Missouri Hospital and Clinics
  • Brian Dieterle, MD, PhD
  • Preventive Medicine
  • Deborah Heart and Lung Center
  • Magaziner Center for Wellness
  • Park Professional Building
  • Stockton Family Practice
  • Bronx-Lebanon Hospital Center
  • Heart Care Center
  • The Gables Natural Medicines Center & Day Spa Family Health Services
  • NYU School of Medicine
  • Rhinebeck Health Center
  • Staten Island Heart
  • Schachter Center for Complementary Medicine
  • Integrative Medical Associates, PLLC
  • Celebration of Health Center
  • University Hospitals of Cleveland
  • The Ohio State University Medical Center
  • Comprehensive Heart Care, Inc.
  • Upper Valley Family Care
  • COR Research
  • St. Charles Health System
  • Center for Environmental Medicine
  • Wholistic Health Center
  • Woodlands Healing Research Center
  • Main Line Health Heart Center
  • Biogenesis Medical Center
  • Athens Surgery Clinic
  • The Castle Clinic, PLLC
  • Chelation Centers of Texas
  • Freedom Center for Advanced Medicine
  • The Cardiovascular Group
  • Virginia Beach General Hospital
  • Hope Medical Holistic Clinic
  • Care Foundation Inc.
  • Waters Preventive Medical Center, LTD
  • Cline Medical Centre
  • The Wellness Centre
  • Chelation Center of Barrie, Inc.
  • Anti-Aging & Family Wellness Clinic
  • Markham Integrative Medicine
  • North Bay Complementary
  • Seekers Centre for Integrative Medicine
  • Dr. C. Minielly
  • Chelation Center of Don Valley Inc.
  • Jaconello Health Centre
  • Chelation and Natural Therapy
  • Chelox
  • Saskatoon Chelation Centre

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Active Comparator

Placebo Comparator

Placebo Comparator

Placebo Comparator

Arm Label

EDTA + high dose vitamin

EDTA + high dose vitamin placebo

EDTA placebo + high dose vitamin

EDTA placebo + high dose vitamin placebo

Arm Description

Participants will receive 40 infusions of active EDTA chelation and active high-dose oral vitamins.

Participants will receive 40 infusions of EDTA chelation and placebo high-dose oral vitamins.

Participants will receive 40 infusions of placebo EDTA chelation and active high-dose oral vitamins.

Participants will receive 40 infusions of placebo EDTA chelation and placebo high-dose oral vitamins.

Outcomes

Primary Outcome Measures

A Composite of Total Mortality, Recurrent Myocardial Infarction, Stroke, Coronary Revascularization, and Hospitalization for Angina.
Number of patients with events (composite of death from any cause, MI, stroke, coronary revascularization or hospitalization for angina) Events were centrally adjudicated where available; otherwise site reported events were used.

Secondary Outcome Measures

A Composite of Cardiovascular Death, Non-fatal Myocardial Infarction and Non-fatal Stroke.
Number of patients with events (composite of cardiovascular death, non-fatal MI, non-fatal stroke) Events were centrally adjudicated where available; otherwise site reported events were used.

Full Information

First Posted
August 22, 2002
Last Updated
August 30, 2013
Sponsor
Mt. Sinai Medical Center, Miami
Collaborators
National Heart, Lung, and Blood Institute (NHLBI), National Center for Complementary and Integrative Health (NCCIH)
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1. Study Identification

Unique Protocol Identification Number
NCT00044213
Brief Title
Trial to Assess Chelation Therapy (TACT)
Official Title
Trial to Assess Chelation Therapy (TACT)
Study Type
Interventional

2. Study Status

Record Verification Date
August 2013
Overall Recruitment Status
Completed
Study Start Date
September 2003 (undefined)
Primary Completion Date
October 2011 (Actual)
Study Completion Date
August 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Mt. Sinai Medical Center, Miami
Collaborators
National Heart, Lung, and Blood Institute (NHLBI), National Center for Complementary and Integrative Health (NCCIH)

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease.
Detailed Description
EDTA chelation therapy involves repeated administrations of a synthetic amino acid to reduce atherosclerotic plaque and other mineral deposits throughout the cardiovascular system. Participants will be randomly assigned to receive 40 infusions of either the standard chelation solution or placebo. The primary endpoint of this trial will be a composite of all cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina. The results of TACT will provide either a significant positive result or an informative null result upon which rational clinical decision-making and health policy can be based.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Coronary Artery Disease

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Factorial Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
1708 (Actual)

8. Arms, Groups, and Interventions

Arm Title
EDTA + high dose vitamin
Arm Type
Active Comparator
Arm Description
Participants will receive 40 infusions of active EDTA chelation and active high-dose oral vitamins.
Arm Title
EDTA + high dose vitamin placebo
Arm Type
Placebo Comparator
Arm Description
Participants will receive 40 infusions of EDTA chelation and placebo high-dose oral vitamins.
Arm Title
EDTA placebo + high dose vitamin
Arm Type
Placebo Comparator
Arm Description
Participants will receive 40 infusions of placebo EDTA chelation and active high-dose oral vitamins.
Arm Title
EDTA placebo + high dose vitamin placebo
Arm Type
Placebo Comparator
Arm Description
Participants will receive 40 infusions of placebo EDTA chelation and placebo high-dose oral vitamins.
Intervention Type
Drug
Intervention Name(s)
EDTA
Intervention Description
Participants will receive 40 infusions of standard chelation solution.
Intervention Type
Drug
Intervention Name(s)
EDTA Placebo
Intervention Description
Participants will receive 40 infusions of EDTA placebo.
Intervention Type
Dietary Supplement
Intervention Name(s)
High Dose Vitamin
Intervention Type
Dietary Supplement
Intervention Name(s)
High Dose Vitamin Placebo
Primary Outcome Measure Information:
Title
A Composite of Total Mortality, Recurrent Myocardial Infarction, Stroke, Coronary Revascularization, and Hospitalization for Angina.
Description
Number of patients with events (composite of death from any cause, MI, stroke, coronary revascularization or hospitalization for angina) Events were centrally adjudicated where available; otherwise site reported events were used.
Time Frame
Measured over a maximum 5-year follow-up period- 55 month median
Secondary Outcome Measure Information:
Title
A Composite of Cardiovascular Death, Non-fatal Myocardial Infarction and Non-fatal Stroke.
Description
Number of patients with events (composite of cardiovascular death, non-fatal MI, non-fatal stroke) Events were centrally adjudicated where available; otherwise site reported events were used.
Time Frame
Measured over a maximum 5-year follow-up period- 55 month median

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria for Participants: Heart attack at least 6 weeks prior to study start Exclusion Criteria for Participants: Serum creatinie level greater than 2.0 mg/dL Platelet count less than 100,000/µL Blood pressure greater than 160/100 Chelation therapy within 5 years prior to study start History of allergic reactions to EDTA or any of the therapy's components Coronary or carotid revascularization procedures within 6 months prior to study start or a scheduled revascularization Cigarette smoking within 3 months prior to study start Childbearing potential History of liver disease Active heart failure or heart failure hospitalization within 6 months. Diagnoses of additional medical conditions that could otherwise limit patient survival Inability to tolerate 500-mL infusions weekly.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Gervasio A Lamas, M.D.
Organizational Affiliation
Icahn School of Medicine at Mount Sinai
Official's Role
Study Director
Facility Information:
Facility Name
Central Arkansas Veterans Healthcare System
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Mt Holistic Health Center
City
Danville
State/Province
California
ZIP/Postal Code
94526
Country
United States
Facility Name
Patrick A. Golden
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
Scripps Center for Integrative Medicine
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Phoenix Wellness Group
City
Napa
State/Province
California
ZIP/Postal Code
94558
Country
United States
Facility Name
Aurora Denver Cardiology Associates
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
The Blend Institute
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34221
Country
United States
Facility Name
Wellness Works
City
Brandon
State/Province
Florida
ZIP/Postal Code
33510
Country
United States
Facility Name
Innovative Research of West Florida
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
White-Wilson Medical Center
City
Fort Walton Beach
State/Province
Florida
ZIP/Postal Code
32547
Country
United States
Facility Name
Hyperbaric Medicine Inc.
City
Ft. Walton Beach
State/Province
Florida
ZIP/Postal Code
32547
Country
United States
Facility Name
Tru Med
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
Mount Sinai Medical Center
City
Miami Beach
State/Province
Florida
ZIP/Postal Code
33140
Country
United States
Facility Name
Baptist Cardiac & Vascular Institute
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Tri-Health Alternative Medical Center
City
Mt. Dora
State/Province
Florida
ZIP/Postal Code
32757
Country
United States
Facility Name
Heart and Vascular Center for Research, Inc.
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Florida Cardiovascular Institute
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
Facility Name
Life Family Practice Center for Complementary and Alternative Medicine
City
The Villages
State/Province
Florida
ZIP/Postal Code
32159
Country
United States
Facility Name
Florida Medical Clinic, P.A. Clinical Research Division
City
Zephyrhills
State/Province
Florida
ZIP/Postal Code
33542
Country
United States
Facility Name
Emory University School of Medicine
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Full Circle Medical Center
City
Fort Oglethorpe
State/Province
Georgia
ZIP/Postal Code
30742
Country
United States
Facility Name
Crossroads Healing Arts LLC
City
Goshen,
State/Province
Indiana
ZIP/Postal Code
46528
Country
United States
Facility Name
Integrative Medical Center at Schneck Medical Center
City
Seymour
State/Province
Indiana
ZIP/Postal Code
47274
Country
United States
Facility Name
Northwest Indiana Cardiovascular Physicians Inc.
City
Valparaiso
State/Province
Indiana
ZIP/Postal Code
46383
Country
United States
Facility Name
Kansas University Medical Center
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Facility Name
The Center for the Improvement of Functioning International
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67219
Country
United States
Facility Name
Complementary Medical Services
City
Mandeville
State/Province
Louisiana
ZIP/Postal Code
70471
Country
United States
Facility Name
Maine Integrative Wellness
City
Portland
State/Province
Maine
ZIP/Postal Code
04103
Country
United States
Facility Name
Johns Hopkins Bayview Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21224
Country
United States
Facility Name
Marino Center for Progressive Health
City
Cambridge
State/Province
Massachusetts
ZIP/Postal Code
02140
Country
United States
Facility Name
Henry Ford Health System Preventative Cardiology Clay Ford Center for Athletic Medicine
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
The Preventive Medicine Center
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Facility Name
Born Preventive Health Care Clinic
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49512
Country
United States
Facility Name
Parchment Family Practice
City
Kalamazoo,
State/Province
Michigan
ZIP/Postal Code
49004
Country
United States
Facility Name
Berman Center for Outcomes and Clinical Research
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Facility Name
Mayo Clinic and Foundation Cardiovascular Health Clinic
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
University of Missouri Hospital and Clinics
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65201
Country
United States
Facility Name
Brian Dieterle, MD, PhD
City
Hollister
State/Province
Missouri
ZIP/Postal Code
65673
Country
United States
Facility Name
Preventive Medicine
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63146
Country
United States
Facility Name
Deborah Heart and Lung Center
City
Browns Mills
State/Province
New Jersey
ZIP/Postal Code
08015
Country
United States
Facility Name
Magaziner Center for Wellness
City
Cherry Hill
State/Province
New Jersey
ZIP/Postal Code
08003
Country
United States
Facility Name
Park Professional Building
City
Roselle Park
State/Province
New Jersey
ZIP/Postal Code
07204
Country
United States
Facility Name
Stockton Family Practice
City
Stockton
State/Province
New Jersey
ZIP/Postal Code
08559
Country
United States
Facility Name
Bronx-Lebanon Hospital Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10457
Country
United States
Facility Name
Heart Care Center
City
East Syracuse
State/Province
New York
ZIP/Postal Code
13057
Country
United States
Facility Name
The Gables Natural Medicines Center & Day Spa Family Health Services
City
Mayville
State/Province
New York
ZIP/Postal Code
14757
Country
United States
Facility Name
NYU School of Medicine
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Rhinebeck Health Center
City
Rhinebeck
State/Province
New York
ZIP/Postal Code
12572
Country
United States
Facility Name
Staten Island Heart
City
Staten Island
State/Province
New York
ZIP/Postal Code
10305
Country
United States
Facility Name
Schachter Center for Complementary Medicine
City
Suffern
State/Province
New York
ZIP/Postal Code
10901
Country
United States
Facility Name
Integrative Medical Associates, PLLC
City
Tryon
State/Province
North Carolina
ZIP/Postal Code
28782
Country
United States
Facility Name
Celebration of Health Center
City
Bluffton
State/Province
Ohio
ZIP/Postal Code
45817
Country
United States
Facility Name
University Hospitals of Cleveland
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
The Ohio State University Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Comprehensive Heart Care, Inc.
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43606
Country
United States
Facility Name
Upper Valley Family Care
City
Troy
State/Province
Ohio
ZIP/Postal Code
45373
Country
United States
Facility Name
COR Research
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
St. Charles Health System
City
Bend
State/Province
Oregon
ZIP/Postal Code
97701
Country
United States
Facility Name
Center for Environmental Medicine
City
Portland
State/Province
Oregon
ZIP/Postal Code
97220
Country
United States
Facility Name
Wholistic Health Center
City
Greensburg
State/Province
Pennsylvania
ZIP/Postal Code
15601
Country
United States
Facility Name
Woodlands Healing Research Center
City
Quakertown
State/Province
Pennsylvania
ZIP/Postal Code
18951
Country
United States
Facility Name
Main Line Health Heart Center
City
Wynnewood
State/Province
Pennsylvania
ZIP/Postal Code
19096
Country
United States
Facility Name
Biogenesis Medical Center
City
Landrum
State/Province
South Carolina
ZIP/Postal Code
29356
Country
United States
Facility Name
Athens Surgery Clinic
City
Athens
State/Province
Tennessee
ZIP/Postal Code
37303
Country
United States
Facility Name
The Castle Clinic, PLLC
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37601
Country
United States
Facility Name
Chelation Centers of Texas
City
Texas City
State/Province
Texas
ZIP/Postal Code
77591
Country
United States
Facility Name
Freedom Center for Advanced Medicine
City
Provo
State/Province
Utah
ZIP/Postal Code
84604
Country
United States
Facility Name
The Cardiovascular Group
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Facility Name
Virginia Beach General Hospital
City
Virginia Beach
State/Province
Virginia
ZIP/Postal Code
23454
Country
United States
Facility Name
Hope Medical Holistic Clinic
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98663
Country
United States
Facility Name
Care Foundation Inc.
City
Wausau
State/Province
Wisconsin
ZIP/Postal Code
54401
Country
United States
Facility Name
Waters Preventive Medical Center, LTD
City
Wisconsin Dells
State/Province
Wisconsin
ZIP/Postal Code
53965
Country
United States
Facility Name
Cline Medical Centre
City
Nanaimo
State/Province
British Columbia
ZIP/Postal Code
V9R 2M9
Country
Canada
Facility Name
The Wellness Centre
City
Port Hawkesbury
State/Province
Nova Scotia
ZIP/Postal Code
V4P 1B5
Country
Canada
Facility Name
Chelation Center of Barrie, Inc.
City
Barrie
State/Province
Ontario
ZIP/Postal Code
L4N9T6
Country
Canada
Facility Name
Anti-Aging & Family Wellness Clinic
City
Madoc
State/Province
Ontario
ZIP/Postal Code
K0K 2K0
Country
Canada
Facility Name
Markham Integrative Medicine
City
Markham
State/Province
Ontario
ZIP/Postal Code
L3P 1Y8
Country
Canada
Facility Name
North Bay Complementary
City
North Bay
State/Province
Ontario
ZIP/Postal Code
P1B 4B8
Country
Canada
Facility Name
Seekers Centre for Integrative Medicine
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K2E 1B3
Country
Canada
Facility Name
Dr. C. Minielly
City
Smith Falls
State/Province
Ontario
ZIP/Postal Code
K7A 1C3
Country
Canada
Facility Name
Chelation Center of Don Valley Inc.
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3C3F2
Country
Canada
Facility Name
Jaconello Health Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4K 3T1
Country
Canada
Facility Name
Chelation and Natural Therapy
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4W 3T1
Country
Canada
Facility Name
Chelox
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6H 3M2
Country
Canada
Facility Name
Saskatoon Chelation Centre
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7M 5W1
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
32446881
Citation
Escolar E, Ujueta F, Kim H, Mark DB, Boineau R, Nahin RL, Goertz C, Lee KL, Anstrom KJ, Lamas GA. Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT). J Diabetes Complications. 2020 Aug;34(8):107616. doi: 10.1016/j.jdiacomp.2020.107616. Epub 2020 May 7.
Results Reference
derived
PubMed Identifier
24987051
Citation
Mark DB, Anstrom KJ, Clapp-Channing NE, Knight JD, Boineau R, Goertz C, Rozema TC, Liu DM, Nahin RL, Rosenberg Y, Drisko J, Lee KL, Lamas GA; TACT Investigators. Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial. Circ Cardiovasc Qual Outcomes. 2014 Jul;7(4):508-16. doi: 10.1161/CIRCOUTCOMES.114.000977.
Results Reference
derived
PubMed Identifier
24490264
Citation
Lamas GA, Boineau R, Goertz C, Mark DB, Rosenberg Y, Stylianou M, Rozema T, Nahin RL, Lindblad L, Lewis EF, Drisko J, Lee KL; TACT (Trial to Assess Chelation Therapy) Investigators. Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial. Ann Intern Med. 2013 Dec 17;159(12):797-805. doi: 10.7326/0003-4819-159-12-201312170-00004.
Results Reference
derived
PubMed Identifier
24254885
Citation
Escolar E, Lamas GA, Mark DB, Boineau R, Goertz C, Rosenberg Y, Nahin RL, Ouyang P, Rozema T, Magaziner A, Nahas R, Lewis EF, Lindblad L, Lee KL. The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT). Circ Cardiovasc Qual Outcomes. 2014 Jan;7(1):15-24. doi: 10.1161/CIRCOUTCOMES.113.000663. Epub 2013 Nov 19.
Results Reference
derived
PubMed Identifier
23532240
Citation
Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, Lindblad L, Lewis EF, Drisko J, Lee KL; TACT Investigators. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA. 2013 Mar 27;309(12):1241-50. doi: 10.1001/jama.2013.2107.
Results Reference
derived
PubMed Identifier
22172430
Citation
Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, Drisko JA, Lee KL. Design of the Trial to Assess Chelation Therapy (TACT). Am Heart J. 2012 Jan;163(1):7-12. doi: 10.1016/j.ahj.2011.10.002.
Results Reference
derived

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Trial to Assess Chelation Therapy (TACT)

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