Ultrasound and Near Infrared Imaging for Predicting and Monitoring Neoadjuvant Treatment
Breast Cancer, Breast Tumors, Cancer of Breast
About this trial
This is an interventional diagnostic trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria:
- Scheduled to receive neoadjuvant chemotherapy for the treatment of newly diagnosed, locally advanced breast cancer or scheduled to receive neoadjuvant endocrine therapy with the eventual goal of surgery of newly diagnosed clinical stage II-III ER+ HER2- breast cancer (for the endocrine therapy cohort)
- At least 18 years of age
- Female
- Able to understand and willing to sign an IRB-approved written informed consent document
Exclusion Criteria:
- Pregnant and/or breastfeeding
- Prior history of breast cancer
- Prior history of chest wall radiation
- Prior history of breast reconstruction, reduction, or augmentation
Sites / Locations
- Washington University School of Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
NIR/US (Neoadjuvant Chemotherapy Cohort)
NIR/US (Neoadjuvant Endocrine Cohort)
Patients will have the NIR/US baseline scan performed before their first treatment. The desirable schedule will be >= 7 days after initial biopsy to avoid confounding effects from the biopsy related acute inflammatory response. In addition, patients will also have NIR/US performed at end of cycle 1, end of cycle 2, end of cycle 3, end of cycle 5 (only if treatment regimen changed), and prior to surgery. The number of NIR/US study visits may vary (5-6) depending on the patient's treatment regimen
Patients will have the NIR/US baseline scan performed before their first treatment. The desirable schedule will be >= 7 days after initial biopsy to avoid confounding effects from the biopsy related acute inflammatory response. In addition, patients will also have NIR/US performed at end of cycle 1, end of cycle 2, end of cycle 3, at time of treatment regimen change (only intended for those who have had a change in their regimen), and prior to surgery. The number of NIR/US study visits may vary (5-6) depending on the patient's treatment regimen