Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia. (FH-Diet)
Familial Hypercholesterolemia, Nutrition, Healthy, Cholesterol, Elevated
About this trial
This is an interventional prevention trial for Familial Hypercholesterolemia focused on measuring familial hypercholesterolemia, diet, LDL-cholesterol, metabolome, cardiovascular disease
Eligibility Criteria
Inclusion criteria:
- Genetically-defined HeFH
- Premenopausal women with a regular menstrual cycle for >3 months
- Postmenopausal women (without hormone replacement)
Exclusion criteria:
- Any cardiovascular disease-risk exacerbating conditions (age >60 years, homozygous FH, personal history of cardiovascular disease, diabetes/anti-diabetic drug use, severe obesity, unstable body weight for >3 months, uncontrolled hypertension, genetic hypertriglyceridemia),
- Allergies/aversions to components of the experimental diets
- Any condition that would interfere with optimal participation in the intervention.
Sites / Locations
- Institute on nutrition and functional foods, Laval UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Canada's Food Guide principles (CFG diet)
Standard North American diet (NAD diet)
During 28 days, participants will receive de CFG diet. The CFG diet emphasizes low intakes of red and processed meats and high intakes of minimally processed plant foods with water as the drink of choice, as per Canada's Food Guide. The number of portions of protein foods, whole-grains, fruits and vegetables to be served daily reflects the recommended ¼-¼-½ proportions. Regarding protein quality, vegetable proteins are served more often than animal proteins as stated in Canada's Food Guide. Weekly, red meat is served once, two days are meatless, and one day is free of animal products.
During 28 days, participants will receive de NAD diet. The NAD diet reflects current dietary intakes of the French-Canadian adult population in terms of foods, nutrients, and diet quality, as characterized in recent surveys conducted in an age- and a sex-representative sample of adults from the Province of Quebec. Intakes of minimally processed fruits and vegetables will be low; animal proteins, mostly red and processed meats, will be consumed more often than vegetable proteins; grains will be mostly refined; and ready-to-eat/ready-to-heat foods and sugary beverages will be served daily.