Use of Muscle Spectroscopy to Evaluate Mitochondrial Dysfunction in HIV-Infected Patients
HIV Infections
About this trial
This is an observational trial for HIV Infections focused on measuring Pilot Projects, Exercise, Phosphorus Isotopes, Mitochondria, Lactates, Magnetic Resonance Spectroscopy
Eligibility Criteria
Inclusion Criteria Participants in Groups 1 and 2 may be eligible for this study if they: Are at least 18 years old. Participants in Group 1 (HIV-uninfected) may be eligible for this study if they: Are HIV-uninfected within 30 days prior to study entry. Participants in Group 2 (HIV-infected) may be eligible for this study if they: Are HIV infected. Have been taking an NRTI-containing anti-HIV drug regimen for 8 weeks or more prior to study entry. Have a nonexercise venous lactate level greater than 2 times the upper limit of normal (ULN) on 2 repeated measurements. Exclusion Criteria Participants in Groups 1 and 2 may not be eligible for this study if they: Have severe claustrophobia. Have severe symptoms that, in the opinion of the investigator, would interfere with the ability of participants to perform the exercise required for spectroscopy testing. Have hepatitis C or B, within 90 days prior to study entry. Have taken certain drugs within 30 days prior to study entry. Have a medical condition associated with chronic liver disease other than hepatitis C and B. Have consumed excessive amounts of alcohol in the past 12 months. Are pregnant or breast-feeding. Have a foreign object or metal in their body that would impair MRS testing. Have or have had peripheral vascular disease. Weigh 250 lbs or more. Have a family history of mitochondrial disease or have skeletal muscle disease, heart muscle disease, or nervous system conditions without a clearly defined cause that is not related to mitochondria. Participants in Group 1 (HIV-uninfected) may not be eligible for this study if they: Have any active medical condition. Use any prescription drugs, except for vitamins or oral contraceptives.
Sites / Locations
- University of Alabama at Birmingham
- University of California, San Diego
- Univ of California, San Diego Antiviral Research Ctr
- Univ of Nebraska Med Ctr
- Univ of Nebraska Medical Ctr
- Beth Israel Med Ctr
- Duke University Medical Center
- Vanderbilt Univ Med Ctr