Use of Platelet-enriched Plasma During Auricular Reconstruction

Use of Platelet-enriched Plasma to Improve the Percentage of Integration of the Cutaneous Graft During Second Stage of Auricular Reconstruction in Children Aged 8-12 Years; A Controlled Clinical Trial

In this study investigators are trying to determine the benefits of using platelet enriched plasma during the second stage of auricular reconstruction. The intervention will be blinded to the surgeon and the surgical team. The main outcome will be the evaluation of the integration rate of the skin full thickness graft used to coat the auricular frame.

In this arm, surgeon will be applying platelet enriched plasma(PEP) (5 ml) during the second stage procedure of auricular reconstruction. PEP will be infected in the temporal fascia used to cover the cartilage frame.

This arm will be used as control. The surgeon will inject 0.9% saline solution (5ml) in a blinded basis.

It is a blinded administration of platelet enriched plasma in the temporal fascia used to cover the auricular reconstruction frame, during the second stage of the procedure. The use of platelet enriched plasma is focused to improve the integration rate of the full-thickness split skin graft

5 ml of saline 0.9%will be applied in the temporal fascia as a placebo used to compare to the experimental group.

Integration rate (in percentage) of the full thickness split graft sued during the second stage of auricular reconstruction.

Evaluation of the integration will be made on clinical basis, and evaluated by 3 experimented plastic surgeons.

It refers to a deviation from the normal course of the pathology, 3 complications will be taken into account: infection, seroma and hematoma

Inclusion Criteria: Microtia Tanzer II-A patients aged 8-12 years Haemoglobin > 10 gr/dL History of first stage of auricular reconstruction Exclusion Criteria: associated endocrinopathies desnutrition (<2.5 gr/ dL)