Using Preoperative Anxiety Score to Determine the Precise Dose of Butorphanol for Sedation
Preoperative Anxiety, Precise Dose of Butorphanol
About this trial
This is an interventional treatment trial for Preoperative Anxiety focused on measuring butorphanol, preoperative anxiety, sedation, recommend dose
Eligibility Criteria
Inclusion Criteria:
- ASA Ⅰ-Ⅱ
- age 18-75 years
- surgical operation of lower extremities in orthopedics
- no contraindication of epidural anesthesia
Exclusion Criteria:
- with central system disease
- with cardiovascular disease
- with autonomic nervous system disease
- long term use of analgesic drugs ,sedative drugs,and anti-anxiety drugs
- language barrier
- unwilling to cooperate with the experimenter
Sites / Locations
- shengjing hospital of China medical university
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Placebo Comparator
Experimental
Placebo Comparator
High anxiety butorphanol group
High anxiety 0.9% saline group
Low anxiety butorphanol group
Low anxiety 0.9% saline group
preoperative anxiety score of Amsterdam pre-operative anxiety and information scale(APAIS) in high anxiety butorphanol group were >10,and received an intravenous loading dose of 15ug/kg butorphanol 5 mins before starting the surgery, then followed by infusion of 7.5ug/kg/h butorphanol and stopped infusion when the Ramsay sedation score (RSS) reached 4
preoperative anxiety score of Amsterdam pre-operative anxiety and information scale(APAIS) in high anxiety 0.9% saline group were >10, and received an infusion of the same volume of 0.9% saline
preoperative anxiety score of Amsterdam pre-operative anxiety and information scale(APAIS) in low anxiety butorphanol group were ≤10,and received an intravenous loading dose of 15ug/kg butorphanol 5 mins before starting the surgery, then followed by infusion of 7.5ug/kg/h butorphanol and stopped infusion when the Ramsay sedation score (RSS) reached 4
preoperative anxiety score of Amsterdam pre-operative anxiety and information scale(APAIS) in low anxiety 0.9% saline group were ≤10, and received an infusion of the same volume of 0.9% saline