Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic
About this trial
This is an interventional diagnostic trial for Bone Marrow Transplant Complications focused on measuring Ultrasound Elastography
Eligibility Criteria
Inclusion Criteria:
Any patient undergoing a myeloablative conditioning regimen for HCT between 4/1/2019 and 12/31/2120 defined as one of the following:
- TBI >= 1200 cGy (fractionated)
- Cyclophosphamide + TBI (> 500 cGy (single) or > 800cGy (fractionated))
- Cyclophosphamide + Etoposide + TBI (> 500 cGy (single) or > 800 cGy (fractionated))
- Cyclophosphamide + Thiotepa + TBI (> 500 cGy (single) or > 800 cGy (fractionated))
- Busulfan (Total dose > 7.2 mg/kg IV or >9.0mg/kg orally) + Cyclophosphamide
- Busulfan (Total dose >7.2 mg/kg IV or >9.0 mg/kg orally) + Melphalan
- Busulfan (Total dose >7.2 mg/kg IV or >9.0 mg/kg orally) + Thiotepa
- NOTE: Busulfan cumulative plasma AUC of >75 mg/L per hour or >18270 microMolar per minute could be used in the preceding criteria in lieu of the mg/kg doses.
OR
2. Any patient who has a myeloablative conditioning regimen (as defined by the local HSCT team) that includes sirolimus and tacrolimus for GVHD prophylaxis.
OR
3. Any patient who is high risk for SOS irrespective of conditioning regimen: Neuroblastoma, HLH, Osteopetrosis, Thalassemia, treatment with inotuzumab or gemtuzumab within 3 months prior to HSCT admission, 2nd HSCT if it is myeloablative and within 6 months of prior, iron overload, steatohepatitis, active inflammatory or infection hepatitis or any other condition which puts the patient at a higher risk of developing SOS.
Exclusion Criteria:
- Any patient who has contraindication to US SWE (e.g. unable to hold still)
Sites / Locations
- Amie RobinsonRecruiting
Arms of the Study
Arm 1
Experimental
Patients Undergoing HCT
All patients enrolled will undergo US SWE at specific time points as outlined in the protocol based on disease course.