Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants

DISEASE CHARACTERISTICS: •Healthy participants Deemed to be in good general health by history and physical examination •Resident of Guanacaste Province of Costa Rica and surrounding areas Must remain a resident for ≥ 6 months after the first study vaccination PATIENT CHARACTERISTICS: Age 18 to 25 Performance status •Not specified Life expectancy •Not specified Hematopoietic •Not specified Hepatic No history of chronic hepatitis requiring treatment No acute or chronic clinically significant hepatic function abnormality by physical examination or laboratory findings No known history of hepatitis A infection Renal No history of kidney disease requiring treatment No acute or chronic clinically significant kidney function abnormality by physical examination or laboratory findings Cardiovascular No acute or chronic clinically significant cardiovascular function abnormality by physical examination or laboratory findings Pulmonary No acute or chronic clinically significant pulmonary function abnormality by physical examination or laboratory findings Immunology No history of allergic disease No history of autoimmune disorder requiring treatment No history of allergic reaction (e.g., difficulty breathing) to any vaccine No suspected allergy or reaction likely to be exacerbated by a component of the study vaccines (e.g., 2-phenoxyethanol or neomycin) No hypersensitivity to latex No diagnosis or suspicion of any immunodeficient condition by medical history or physical examination Other Not pregnant or nursing ◦No delivery within the past 3 months Negative pregnancy test Fertile patients must use effective contraception for 30 days before, during, and for 60 days after completion of study treatment Able to speak or understand Spanish Mentally competent Able to undergo pelvic exam (i.e., no heavy bleeding [menstruation or otherwise] or heavy vaginal discharge) No history of cancer requiring treatment No history of diabetes requiring treatment No history of other chronic conditions requiring treatment No acute or chronic clinically significant neurologic function abnormality by physical examination or laboratory findings No other acute disease No fever ≥ 37.5º C PRIOR CONCURRENT THERAPY: Biologic therapy More than 6 months since prior chronic administration (i.e., > 14 days) of immune-modulating drugs More than 90 days since prior immunoglobulins More than 30 days since prior and no other concurrent investigational or non-registered vaccines More than 30 days since prior registered vaccines More than 8 days since prior routine meningococcal, hepatitis B, influenza, or diphtheria/tetanus vaccine No prior vaccination against hepatitis A No prior vaccination against human papillomavirus No prior monophosphoryl lipid A or AS04 adjuvant Chemotherapy •Not specified Endocrine therapy More than 6 months since prior chronic administration (i.e., > 14 days) of corticosteroids (e.g., ≥ 0.5 mg/kg/day of prednisone or equivalent) Concurrent inhaled or topical steroids allowed Radiotherapy •Not specified Surgery •No prior hysterectomy Other More than 6 months since prior chronic administration (i.e., > 14 days) of immunosuppressants More than 30 days since prior and no other concurrent investigational or non-registered drugs