Validation Of Quantitative Flow Ratio (QFR) - Derived Virtual Angioplasty (QIMERA-I)

Prospective intervention study to assess the accuracy of the predicted QFR-derived virtual angioplasty compared to hyperaemic and non-hyperaemic pressure-wire derived indexes after PCI, as well as with QFR post-PCI.

Patients submitted to a coronary angiogram with at least one non-left main stable coronary stenosis between 50 and 90% and PCI indication with paired assessment of QFR, dFR, RFR and FFR, before and after PCI once informed consent is provided.

Quantitative flow ratio (QFR) is a novel approach enabling rapid computation of FFR pullbacks from three-dimensional quantitative coronary angiography (3D-QCA) without using a pressure wire.

Numerical agreement between predicted post PCI QFR (residual QFR) and post PCI dPR RFR-FFR, as well as direct QFR post-PCI mesurement.

Identification of independent predictors for increased predicted postPCI QFR (residual QFR) and post PCI dPR-RFR-FFR.

Inclusion Criteria: Patients submitted to a coronary angiogram with at least one non-left main stable coronary stenosis with PCI indication. Exclusion Criteria: Severe stenosis of the left main coronary artery. Patients admitted with ST-elevation myocardial infarction. Culprit lesions in Non-ST-Elevation Acute Coronary Syndromes (NSTEACS) patients. Unability to identify the culprit lesion in NSTE-ACS patients.

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