Valproate in Dementia (VALID)

Inclusion Criteria: Probable AD by National Institute of Neurological Disorders and Stroke (NINDS)-Alzheimer's Disease and Related Disorder Association (ADRDA) criteria. Males or females. > 55 and < 90 years of age. Weight > 40 kg (88.2 lbs.). Residing in the community at Screen and Baseline. Participants may reside in assisted living facilities, but not in long-term care nursing facilities or assisted living facilities that provide intensive support for people with dementia nor may they reside in a secure unit necessary for behavioral management. Mini Mental State Examination (MMSE) at Screen and Baseline 12-20 inclusive. Computed tomography (CT) or magnetic resonance imaging (MRI) since onset of dementia consistent with the diagnosis of probable AD. Single lacunes in non-critical areas and non-specific white matter changes that are interpreted as age-related are not grounds for exclusion. Any ambiguous scan results must be reviewed with the Project Director. Fluent in English or Spanish. Supervision available for study medication. Study partner to accompany subject to all visits. Study partner must have in-person contact with the participant > 2 days/week. Able to ingest oral medication. Total Neuropsychiatric Inventory (NPI) score for previous 4 weeks < 8 at Screening, and for the period between Screening and Baseline. NPI item score for the items assessing delusions, hallucinations, agitation/aggression all greater than or equal to 1 for 4 weeks prior to Screening (less than once/week and mild severity at most) and for the period between Screening and Baseline. Scores of greater than or equal to 1 for items rating delusions, hallucinations, and agitation/aggression taken from the NPI, modified to assess these features since onset of illness. This will be derived from a second interview with the modified NPI. (Agitation/psychosis during episodes of delirium are not considered exclusionary.). Exclusion Criteria: Exceptions to these criteria may be considered on a case-by-case basis at the discretion of the Project Director: Non-AD dementia. Females of child-bearing potential. Residence in a long-term care facility or equivalent at Baseline. Presence or previous history of agitation or psychosis requiring active psychotropic medication since the illness began. History of clinically significant stroke. Current evidence or history in past two years of: focal brain lesion, head injury with loss of consciousness or Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for any major psychiatric disorder including psychosis, major depression, bipolar disorder, alcohol or substance abuse. Sensory impairment that would prevent subject from participating in or cooperating with the protocol. Medical contraindications to study participation. Use of another investigational agent within two months prior to Screening. Evidence of any significant clinical disorder or laboratory finding that renders the subject unsuitable for receiving an investigational new drug including clinically significant or unstable hematologic, hepatic, cardiovascular, pulmonary, gastrointestinal, endocrine, metabolic, renal, or other systemic disease or laboratory abnormality. Clinical contraindication to the use of valproate (e.g., known hypersensitivity or allergic reactions, severe neutropenia, severe hepatic disease, or urea cycle disorder. A urea cycle disorder should be considered in patients with history of unexplained encephalopathy following protein meals, or family history of urea cycle disorder). History of seizure within past 5 years prior to Screening. Platelet count < 100,000/mm^3. International Normalized Ratio (INR) > 1.2 or partial thromboplastin time (PTT) > 40 seconds. Active neoplastic disease. Exceptions: skin tumors other than melanoma are not excluded; patients with stable prostate cancer may be included at the discretion of the Project Director; women who have been treated for breast cancer and have no metastases and whose survival is expected to exceed 2 years may be considered for inclusion on a case-by-case basis in consultation with the Project Director; patients with purely localized bladder wall cancers may be included at the discretion of the Project Director. Excluded Medications: Use of psychotropics for treatment of agitation or psychosis. Antidepressants used in stable doses for 3 months prior to Screening to treat depression or anxiety, but not agitation, will be permitted. Low dose sedatives for sleep, but not agitation, will be permitted. Cholinesterase inhibitors used in stable doses for at least 3 months prior to Screening are permitted. Regular use of narcotic analgesics within 3 months of Screening. Anti-parkinsonian medications (e.g. levodopa, selegiline, pergolide, bromocriptine, pramipexole) within 2 months of Screening. Use of drugs with significant central anticholinergic or antihistaminic effects (eg, benztropine, trihexyphenidyl, dicyclomine, diphenhydramine, cyproheptadine, diphenoxylate, hydroxyzine, meclizine, prochlorperazine, promethazine) within 2 months of Screening. Use of other investigational drug studies within two months prior to Screening. Use of other anticonvulsants within 5 years prior to Screening. Use of zidovudine at any time. Use of tricyclic antidepressants within 1 month prior to Screening. Regular use of high doses of salicylates at Screening (> 1,300 mg/d). Vitamin E > 2,100 IU/d within 1 month prior to Screening. Warfarin use is permitted when approved by the Project Director and INR and PTT criteria are met.