Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease (ENTERPRISE)
Crohn's Disease
About this trial
This is an interventional treatment trial for Crohn's Disease focused on measuring Drug therapy, Fistulizing Crohn´s disease, Perianal Fistula
Eligibility Criteria
Inclusion Criteria:
- In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
- The participant or, when applicable, the participant's legally acceptable representative has signed and dated a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
- Has a diagnosis of CD established at least 3 months prior to randomization by clinical and endoscopic evidence and corroborated by a histopathology report.
- Has a diagnosis of a minimum of 1 perianal draining fistula of at least 2 weeks duration as a complication of moderately to severely active CD, as identified on magnetic resonance image (MRI) at Screening. Other types of fistulae (enterocutaneous, abdominal) except rectovaginal fistulae are permitted, but the number of perianal draining fistulae is limited to 3.
All countries except France: The participant, historically, had an inadequate response with, lost response to, or was intolerant to either conventional therapy or a tumor necrosis factor-alpha (TNF-α) antagonist for their underlying CD (does not require treatment failure for currently active draining fistula).
France only: The participant, historically, failed (ie, had an inadequate response with, lost response to, or was intolerant to) infliximab for treatment of their underlying CD or fistulizing CD.
- If the participant had noncutting perianal seton placement as part of standard care, seton must be removed by Week 14 of the study.
Exclusion Criteria:
- Has a diagnosis of ulcerative colitis or indeterminate colitis.
- Has a perianal abscess greater than (>) 2 centimeter (cm) or an abscess that the investigator feels requires drainage based on either clinical assessment or MRI.
- Has a Crohn's Disease Activity Index (CDAI) score >400.
- Has an ileostomy, colostomy, or known fixed symptomatic stenosis of the intestine.
- Has significant anal or rectal stenosis.
- Has active or latent tuberculosis (TB), regardless of treatment history.
- Has evidence of active Clostridium difficile (C. difficile) infection or is having treatment for C. difficile infection or other intestinal pathogens during Screening.
- Has current rectovaginal fistula.
- Currently has more than 3 draining perianal fistulae. Note: Other protocol-defined inclusion/exclusion criteria may apply
Sites / Locations
- Vanderbilt University Medical Center
- Texas Digestive Disease Consultants
- Virginia Mason Medical Center
- University of Calgary
- GIRI (GI Research Institute)
- CHRU de Lille - Hopital Claude Huriez
- Hopital l'Archet II
- CHU de Rennes - Hopital de Pontchaillou
- Hopital de Brabois
- Azienda Ospedaliera S. Orsola-Malpighi
- Istituto Clinico Humanitas IRCCS
- Academic Medical Center
- Leids Universitair Medisch Centrum
- Erasmus MC
- Hospital Clinic Barcelona
- Hospital Universitario y Politecnico La Fe
- Nottingham University Hospitals NHS Trust
- John Radcliffe Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Group 1: Vedolizumab IV 300 mg + Placebo
Group 2: Vedolizumab 300 mg
Vedolizumab 300 mg, IV infusion, once, at Weeks 0, 2, 6, 14, and 22, and vedolizumab placebo-matching, IV infusion once, at Week 10 to maintain the blind.
Vedolizumab 300 mg, IV infusion, once, at Weeks 0, 2, 6, 10, 14, and 22.