VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide

Inclusion Criteria: International Normalized Ratio (INR) < = 1.5 Platelet count => 100,000/mm³ Hemoglobin => 10 g/dL (transfusion allowed) Serum glutamic oxaloacetic transaminase (SGOT)/Serum glutamic pyruvic transaminase (SGPT) < = 2 times upper limit of normal (ULN) Not pregnant or nursing Negative pregnancy test No previous Vascular endothelial growth factor (VEGF) Trap At least 4 weeks since chemotherapy, surgery, or open biopsy At least 2 weeks since vincristine At least 6 weeks since carmustine, lomustine, fotemustine, or radiation therapy At least 42 days since prior nitrosoureas At least 3 weeks since procarbazine No previous Gliadel wafers or bevacizumab Tumor did not respond to previous radiation therapy and temozolomide Karnofsky performance status (KPS) 60-100% Life expectancy = > 8 weeks White blood count (WBC) = >3,000/mm³ Absolute neutrophil count = > 1,500/mm³ Bilirubin < = 2 times ULN Creatinine < = 1.5 mg/dL OR creatinine clearance= > 60 mL/min Urine protein:creatinine ratio < = 1 OR 24-hour urine protein < = 500 mg/dL Fertile patients must use effective contraception prior to, during, and for = > 6 months after completion of study treatment No significant medical illnesses that, in the opinion of the investigator, cannot be adequately controlled with appropriate therapy or would preclude compliance with study treatment No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies No history of allergic reactions attributed to compounds of similar chemical or biological composition to other agents used in the study No history of any other cancer (except nonmelanoma skin cancer or carcinoma in situ of the cervix), unless in complete remission and off of all therapy for that disease for = >3 years At least 7 days since prior noncytotoxic agents (e.g., interferon, tamoxifen, thalidomide, or isotretinoin [radiosensitizer does not count]) At least 7 days since prior core biopsy At least 28 days since prior investigational agents No prior bevacizumab or vascular endothelial growth factor receptor inhibitors No concurrent full-dose anticoagulants (e.g., warfarin or low molecular-weight heparin) No clinically significant cardiovascular disease, including any of the following: Cerebrovascular accident within the past 6 months Uncontrolled hypertension, defined as blood pressure (BP) > 140/90 mm Hg or systolic BP > 180 mm Hg if diastolic BP < 90 mm Hg, on ≥ 2 repeated determinations on separate days within the past 3 months Myocardial infarction, coronary artery bypass graft (CABG), or unstable angina pectoris within the past 6 months New York Heart Association class III-IV congestive heart failure No serious cardiac arrhythmia requiring medication Clinically significant peripheral vascular disease within the past 6 months Pulmonary embolism, deep vein thrombosis, or other thromboembolic event within the past 6 months No evidence of bleeding diathesis or coagulopathy No more than 1 prior chemotherapy regimen (initial treatment and treatment for 1 relapse) Surgical resection for relapsed disease with no anticancer therapy instituted for up to 12 weeks followed by another surgical resection is considered 1 relapse If prior therapy for a grade 3 glioma was given, surgical diagnosis of a high-grade glioma is considered the first relapse Prior surgical, interstitial brachytherapy, or stereotactic radiosurgery not considered prior therapy If prior therapy included interstitial brachytherapy or stereotactic radiosurgery, must have confirmation of true progressive disease rather than radiation necrosis based upon either positron emission tomography (PET) scan, thallium scanning, Magnetic Resonance (MR) spectroscopy, or surgical documentation of disease Must show unequivocal radiographic evidence of tumor progression by MRI Recent resection of recurrent or progressive tumor allowed Residual disease not required Temozolomide-resistant recurrent glioblastoma is defined as tumor progression or tumor recurrence during or after treatment with temozolomide-based chemotherapy regimens Recovered from prior therapy No other disease that would obscure toxicity or dangerously alter drug metabolism No uncontrolled intercurrent illness, including, but not limited to, any of the following: Ongoing or active infection Psychiatric illness or social situations that would limit compliance with study requirements No serious or nonhealing wound, ulcer, or bone fracture No history of intracerebral or intratumoral hemorrhage No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 28 days No significant traumatic injury within the past 28 days At least 28 days since prior cytotoxic therapy Histologically confirmed diagnosis of 1 of the following: Intracranial glioblastoma or gliosarcoma Anaplastic astrocytoma Anaplastic oligodendroglioma Anaplastic mixed oligoastrocytoma Malignant astrocytoma not otherwise specified NOTE: If original histology was grade 3 glioma, subsequent histological diagnosis of 1 of these diseases is allowed provided no prior diagnosis of grade 2 glioma At least 20 unstained slides OR 1 tissue block available from original diagnostic biopsy/surgery or from biopsy/surgery at recurrence Patients presenting at the time of first recurrence or relapse, defined as progression after initial therapy (i.e., radiotherapy +/- chemotherapy if that was used as initial therapy) are eligible No other concurrent investigational drugs No other concurrent investigational drugs No concurrent cytotoxic or noncytotoxic therapy, including chemotherapy, radiotherapy, hormonal therapy, or immunotherapy No concurrent major surgery No concurrent combination antiretroviral therapy for HIV-positive patients Concurrent anticonvulsant therapy allowed