Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Attachment Loss, Periodontal, Teeth, Impacted
About this trial
This is an interventional treatment trial for Attachment Loss, Periodontal focused on measuring third molar surgery, amelogenin, periodontal pocket
Eligibility Criteria
Inclusion Criteria:
- Patients aged < 27, for which the extraction of both lower third molars was indicated
- Bilateral total (bone or osteo-mucosal) third molar impaction
- Bilateral bone defect ≥ 5mm distal to the lower second molars, evaluated on pre- operative periapical radiographs performed with Rinn's film holders
- PPD ≥ 8mm distal to the second lower molars, in at least one of the following probing sites: buccal, disto-buccal, disto-central, disto-lingual
- Intra-operative integrity of both third molar buccal and lingual alveolar cortices
Exclusion Criteria:
- Smoking habit
- Systemic disorders with serious immunologic impairment
- Taking cortisone or other drugs that might interfere with healing process
- Allergy to penicillins
- Previous periodontal treatment
- Less than 2 mm of adherent gingiva at second molar level
- Second molars with a prosthetic crown
- Previous endodontic treatment of second molars
- Furcation involvement of the second molars
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
amelogenins group
placebo group
The study involved enrolling 5 periodontitis free patients, to which the extraction of both lower third molars was prescribed. A bone defect at the distal surface of the second molar ≥ 5 mm, had to be present on the intraoral periapical radiography, bilaterally. Amelogenins effect was evaluated by applying them only in the test site and comparing healing results with those obtained on the contra-lateral site
The study involved enrolling 5 periodontitis free patients, to which the extraction of both lower third molars was prescribed. A bone defect at the distal surface of the second molar ≥ 5 mm, had to be present on the intraoral periapical radiography, bilaterally. In this group (control site) the conventional treatment was performed, and healing was ensured only by the simple blood clot