Very Early veRsus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes (VERDICT-EDI)
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring Coronary Stenosis, Coronary Artery Disease, Acute coronary syndrome, Percutaneous Coronary Intervention, Multidetector Computed Tomography
Eligibility Criteria
Inclusion Criteria:
Patients with clinical suspicion of of UAP/NSTEMI acute coronary syndrome deemed suitable for invasive evaluation and treatment will be included in the study.
- Age> 18 years
- At least one of the following:
- ECG abnormalities suggestive of myocardial ischemia (newly developed ST segment depression, horizontal or descending >= 0,05mV in two anatomically adjacent leads and/or T-wave inversion >0,01 mV in two leads with prominent R wave or R/S ratio >1
- Elevated myocardial ischemia biomarkers (Troponin, CK-MB)
Exclusion Criteria:
- Pregnancy
- Circumstances preventing the patient from reading and/or understanding the research protocol information
- Clinical indication for acute invasive coronary angiography - severe chest pain despite intravenous nitroglycerin infusion or hemodynamic instability
- Expected survival of less than 1 year
- Known allergy/hypersensitivity of pharmacological platelet inhibitors and/or iodine contrast that cannot be prevented medically
Patients with known eGFR below 60 ml/min will not undergo CCTA, whereas patients in dialysis will undergo the entire study protocol
Sites / Locations
- Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Deferred invasive evaluation
Very early invasive evaluation
Deferred invasive coronary evaluation and revascularization (PCI/CABG) within 72 hours from time of clinical diagnosis (CONTROL group)
Acute invasive coronary evaluation within 12 hours from time of diagnosis - INTERVENTION group