Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis, Respiratory Failure, Respiratory Insufficiency
About this trial
This is an interventional treatment trial for Amyotrophic Lateral Sclerosis focused on measuring Non-invasive ventilation, Home ventilation, iVAPS-AE
Eligibility Criteria
Inclusion Criteria:
Patients with respiratory failure secondary to ALS (diagnosed either at an MND MDT or specialist neurology clinic) according to criteria set out in the NICE guideline (NG42) (2016); Motor neurone disease: assessment and management.
- Patients able to provide informed consent to take part in the research study.
- Patients not contraindicated to commence NIV in accordance with local protocol.
- Patients not currently enrolled in another research study that could alter disease progression.
Exclusion Criteria:
- Acutely unwell or medically complicated patients as assessed by lead investigator. These patients will be urgently reviewed by a dedicated Consultant Physician. The Principal Investigator will be immediately informed.
- An inability to provide informed consent.
- An inability to use NIV.
- Patients whom are contraindicated to commence NIV in accordance with local protocol.
Sites / Locations
- University Hospital Coventry and Warwickshire NHS TrustRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
iVAPS-AE
ST-mode
Patients with ALS and respiratory insufficiency randomised to this arm will be treated with home NIV using the Intelligent Volume-Assured Pressure Support with automatic EPAP (iVAPS-AE) mode.
Patients with ALS and respiratory insufficiency randomised to this arm will be treated with home NIV using the spontaneous timed (ST) home NIV mode.