Walking Pattern Characteristics in Normal Pressure Hydrocephalus (NPH wearables)
Idiopathic Normal Pressure Hydrocephalus (INPH)
About this trial
This is an interventional diagnostic trial for Idiopathic Normal Pressure Hydrocephalus (INPH)
Eligibility Criteria
Age limits for the NPH patient group and the matched healthy vonunteers group are 60-100 years.
Age limits for the young healthy volunteers group are 18-40 years.
Inclusion Criteria:
NPH patient group:
- Informed Consent as documented by signature prior to any study related procedures or informed consent by a legal representative in case of cognitive deficits.
- Male and female patients alike
- Age between 60 and 100 years
- Clinical suspect for NPH
- Significant improvement (by more than 10%) in walking speed or endurance in a standardized CSF-TAP test (of at least 35 ml CSF).
- Planned implantation of a VP shunt for NPH treatment (independently from the study).
Matched controls group:
- Informed Consent as documented by signature prior to any study related procedures
- Male and female patients alike (matched to group 1)
- Age between 60 and 100 years (matched to group 1)
- No clinical suspect for NPH or any other movement disorder
Young controls group:
- Informed Consent as documented by signature prior to any study related procedures
- Male and female patients alike (matched to group 1)
- Age between 18 and 40 years
- No clinical suspect for NPH or any other movement disorder
Exclusion Criteria:
- Enrolment of the investigator, his/her family members, employees and other dependent persons (only for patients; no exclusion criteria for controls),
- Apparent or suspected movement disorder or other known disorder, which might affect normal standing or walking
- Cardiovascular disorders, which might affect physical resilience
- Pregnant women
- Pre-menopausal state of female patients and probands in groups 1 and 2.
- Children and adolescents
Sites / Locations
- Dept. of Neurosurgery, Zurich University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
iNPH patients
Healthy volunteers
Young healthy volunteers
20 patients with completed diagnostics concerning NPH, in which the indication for implantation of a VP shunt for NPH treatment was found by the responsible surgeon independently from the study.
20 volunteers, matched with group 1 concerning sex and age.
20 volunteers, matched with group 1 concerning sex only and between 18 and 40 years old.