Weight Loss Intervention With Lean Muscle Mass Retention (WLMR)
Overweight and Obesity
About this trial
This is an interventional other trial for Overweight and Obesity focused on measuring Body Weight, Body Fat, Muscle Mass
Eligibility Criteria
Inclusion Criteria: Male or Female Chinese ethnicity Age between 40 to 69 years Able to give informed consent Body Mass Index (BMI) between 23.0 to 32.5 kg/m2 Exclusion Criteria: Smoking Having allergies or intolerances to any common food ingredients including eggs, fish, milk, peanuts, and tree nuts, shellfish, soya, wheat, gluten, cereal, fruits, dairy products, meat, vegetable, sugar and sweetener, natural food colourings or flavourings, etc Following special diets or having intentional dietary restrictions (e.g, vegetarians/vegans) Not willing to stop consumption of probiotic or prebiotic supplements within 4 weeks prior to start of study if currently taking these, as well as during study participation Not willing to adhere to diet modification as in the study protocol Not willing to adhere to the exercise regime as in the study protocol Taking part in strenuous physical activities Not willing to stop any strenuous activity during or within 24 hours of test days (for those actively participating in sports at the competitive and/or endurance levels) Having glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) Having alcohol consumption on > 4 days per week with ≥ 6 alcoholic drinks per week Having sustained elevation of blood pressure (>160/95 mm Hg) Having previously undergone any gastrointestinal surgery or having history of gastrointestinal disorders Having a history of heart, liver, kidney, blood disorders (e.g., thalassemia) or thyroid dysfunctions Diabetic Having history of tuberculosis, HIV, Hepatitis B or Hepatitis C infections Having any prescription medication or any other alternative medicines or supplements which may interfere with study measurements in the in the opinion of the study investigators Having antibiotics or suffering from diarrhea within the last 3 months Having donated blood within 4 weeks of study participation Having poor veins or having history of severe vasovagal syncope (blackouts or fainting) from blood draws Having more than 5% weight loss or gain over the past 3 months Having metallic implants, pacemaker in the body Having claustrophobia Having a musculoskeletal injury, joint or peripheral vascular disease sufficient to impede exercise (such as hip arthritis, foot, ankle problems or pain) Having severe exercise-induced asthma Staff of Wilmar International and/or Singapore Institute of Food and Biotechnology Innovation (SIFBI) For female volunteers: menstruation within past 12 months or being on hormone replacement therapy
Sites / Locations
- Clinical Nutrition Research Centre
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Low-Calorie Control Group
Low-Calorie Treatment Group
The control group will receive 2x calorie-restricted balanced meals per day, each consisting of a portion of animal proteins (~20g), a portion of vegetables, and a portion of starch (rice/ noodles) per meal. The group will also receive a mid-morning beverage in the form of a malted drink (~150 kcal and ~5g protein). The third meal of the day and any additional snacks will be left to the free choice of the participants, with calorie advice provided by study dietitian. Calorie restriction aims to reduce body weight of individual participants by ~5 - 10%. The group will also be asked to undergo a supervised mixed exercise regime three days per week, 1 hour per day. The mixed exercise regime will consist of 2 sessions of resistance training and 1 session of aerobic training.
The treatment group will receive 2x calorie-restricted balanced meals per day, each consisting of a portion of plant proteins (~25g), a portion of vegetables, and a portion of starch (rice/noodles) per meal. The group will also receive a mid-morning beverage, in the form of a soy-based, plant protein beverage (~120 kcal and 13g protein). The third meal of the day and any additional snacks will be left to the free choice of the participants, with calorie advice provided by study dietitian. Calorie restriction aims to reduce body weight of participants by ~5 - 10%. The group will also be asked to undergo a supervised mixed exercise regime three days per week, 1 hour per day. The mixed exercise regime will consist of 2 sessions of resistance training and 1 session of aerobic training.