WHO COVID-19 - Evaluation of the Efficacy of Probiotics to Reduce the Occurrence of Long COVID (PROVID-LD)
COVID-19
About this trial
This is an interventional treatment trial for COVID-19 focused on measuring Long COVID, COVID-19, Sars-CoV-2, Coronavirus, Probiotics
Eligibility Criteria
Inclusion Criteria:
- 18 years and over
- ≤ 10 days between the COVID-19 diagnosis and the inclusion
- Having symptoms of the COVID-19 at inclusion
- Living in Quebec for the next 90 days
- Self-caring at home
- Able to take medication alone
- With access to a phone or to the Internet
- Able to give informed consent
Exclusion Criteria:
- Taking probiotic supplements at inclusion
- Taking antibiotics for a reason other than COVID-19 at inclusion
- Allergies to soy, lactose, yeast, maltodextrin, vitamin C, potato starch, magnesium stearate, hypromellose or titanium dioxide
- Has a chronically weakened immune system (AIDS, lymphoma, chemo-radio-corticosteroid therapy, immunosuppressive pathology)
- Was treated with chemo-radio-corticosteroid therapy in the last 6 months
- Has active cancer
- Taking immunosuppressive drugs (e.g. anti-rejection treatment after organ transplant)
- Already participating in another randomized clinical trial
- Is pregnant, expects to become pregnant in the next few months or is breastfeeding
- Has any other condition that would prevent safe participation in the study
Sites / Locations
- CIUSSS de L'Estrie-CHUS Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Probiotics
Placebo
Two probiotic strains will constitute the experimental arm (Probiotics). Participants will take two capsules per day (one closed capsule to swallow and one open capsule mixed with maple syrup) for 10 days and one closed capsule per day to swallow for the following 15 days. They will stop the treatment if they are admitted to the hospital. The treatment will last a maximum of 25 days.
Potato starch and magnesium stearate will constitute the comparator arm (Placebo). Participants will take two capsules per day (one closed capsule to swallow and one open capsule mixed with maple syrup) for 10 days and one closed capsule per day to swallow for the following 15 days. They will stop the treatment if they are admitted to the hospital. The treatment will last a maximum of 25 days.