Will Decreased Noradrenergic Activity Normalize Information Processing in Patients With Schizophrenia?
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Schizophrenia, Information processing, PPI, P50 gating, P300, mismatch negativity, clonidine
Eligibility Criteria
Inclusion Criteria: Patients: Male subjects Meeting the DSM-IV diagnosis of schizophrenia Controls: Male subjects Good Physical and Mental Health meeting criteria "never mentally ill", which will be evaluated with a medical history checklist Non smokers Exclusion Criteria: Patients: A P50 suppression or PPI score falling within a range of 10 percent above or below the mean score of the healthy control group Controls: Current use of any medication Any subject who has received any investigational medication within 30 days prior to the start of this study History of neurologic illness History of psychiatric illness in first-degree relatives, evaluated with DSM-IV criteria History of alcohol and drug abuse.
Sites / Locations
- Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Center Glostrup
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
1
2