Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs
HIV Infections, Histoplasmosis
About this trial
This is an observational trial for HIV Infections focused on measuring AIDS-Related Opportunistic Infections, Histoplasmosis, Antifungal Agents, Recurrence, Anti-HIV Agents
Eligibility Criteria
Inclusion Criteria Patients may be eligible for this study if they: Are 13 years or older. Have consent of parent or guardian if under 18 years of age. Have HIV infection. Have 2 CD4 cell counts above 150 cells/mm3 (1 of which has been obtained within 6 months and the other within 30 days before entry). Note: The 2 CD4 counts used for eligibility must be from tests performed at least 1 week apart. Have received at least 1 year of treatment for histoplasmosis. (This study has been changed to include patients who have received histoplasmosis treatment with drugs other than itraconazole.) Are receiving treatment for histoplasmosis or have stopped treatment within 24 weeks of study entry. Have had histoplasmosis before but are free of any signs of histoplasmosis at entry into the study. Have a negative pregnancy test within 14 days of study entry. Have been on anti-HIV drugs for at least 24 successive weeks and have been on a stable anti-HIV drug combination for at least 8 weeks before entry. Exclusion Criteria Patients will not be eligible for this study if they: Have any recurrence of histoplasmosis within 4 weeks of study entry. Have received medications that affect the immune system including chemotherapy or corticosteroids within the last 2 months. (This study has been changed. Patients taking IL-2 are no longer excluded.) Have a systemic infection. Patients on stable preventive treatment for certain opportunistic (AIDS-related) infections for at least 3 months will be eligible. Require treatment for fungal infections with systemic antifungal medications. Have meningitis or brain or spinal cord damage thought to be caused by Histoplasma infection.
Sites / Locations
- Univ of Southern California / LA County USC Med Ctr
- University of California San Francisco
- Emory Univ
- Cook County Hosp
- Indiana Univ Hosp
- Methodist Hosp of Indiana / Life Care Clinic
- Wishard Hosp
- Univ of Nebraska Med Ctr
- Bellevue Hosp / New York Univ Med Ctr
- Univ of Cincinnati
- Ohio State Univ Hosp Clinic
- Julio Arroyo
- Univ of Texas, Southwestern Med Ctr of Dallas