Wound Healing Effects of HO/03/03 In Patients With Diabetic Neuropathic Plantar and Venous Ulcers, Pilot Study.

Inclusion Criteria: Patients must satisfy all of the following inclusion criteria to be included in the study: be male or female over the age of 18; have a diabetic neuropathic plantar and/or venous ulcer; wound diameter <10cm; wound depth is no more than exposed muscle; have a current physical examination, which reveals no clinically significant abnormalities, except diabetes or diabetic ulcer/wound related condition be available for the entire study period, and be able and willing to adhere to protocol requirements; vascular inflow as measured by Doppler: ABI >= 0.7 have a debilitating wound over a period of 1 month prior to the experiment; if female of childbearing potential, must be using a reliable form of birth control; provide written informed consent prior to admission into the study. Exclusion Criteria: Patients will be excluded from the study if they meet any of the following exclusion criteria: have a body mass index (BMI) > 45; have a glycosylated hemoglobin (HbAlc) > 12.0%; have a history or presence of HIV or a clinically significant cardiac, gastrointestinal, endocrine, neurological, liver, or kidney disease; have any clinically significant illness during the 4 weeks prior to admission into the study, except diabetes type1 or type2; patients on concomitant medications that alter blood glucose levels (e.g., ACE inhibitors, lipid lowering agents, etc) must be on a stable dosage regimen for at least 4 weeks prior to entry into the study and the dosage must remain stable throughout the study; patients on chemotherapy; participation in a clinical study or use of an investigational drug within 30 days prior to admission to this study; are pregnant or lactating; visible bone exposure at wound site; have any signs of clinical infection in the wound (which could be linked to raised body temperature), necrosis, erythema or mild drainage; have any acute illness within 2 weeks prior to Screening; residing in a nursing facility and/or are bed-ridden (unable to come to receive treatment at the clinic);