Complication in Laparoscopic Renal and Adrenal Surgery (CLARAS)
Adrenal DiseaseRenal Cancer1 morethe aim of this study is clarify complication and their resolution in laparoscopic renal and adrenal surgery.
Comprehensive Data Collection and Follow-Up for Patients With Thyroid, Parathyroid and Adrenal Disease...
Endocrine DiseaseThe goal of this data review study is to collect data to learn more about thyroid, parathyroid, and adrenal disease.
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy
Adrenal TumorAdrenal Disease11 moreThe goal of this multicenter, observational, analytic, randomized clinical trial is to analyze the laparoscopic and robot-assisted method in the surgical treatment of patients with adrenal diseases. The main question it aims to answer are: to find the superiority of one the the surgical method mentioned above to compare the quality of life in patients with adrenal mass before surgery and after laparoscopic or robotic-assisted adrenalectomy.
Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative Study
Adrenal MassAdrenal Disease2 moreThis randomized comparative study assesses the safety and efficacy of the posterior retroperitoneoscopic adrenalectomy in comparison to the standard, anterior transperitoneal approach and suppose that this new technique is a safe and effective alternative to the standard approach.
Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia
Congenital Adrenal HyperplasiaHyperplasia11 moreThis is an open-label, non-randomized crossover design feasibility trial comparing oral hydrocortisone treatment with interval bolus delivery (pulsatile) of subcutaneous hydrocortisone via infusion pump in children with congenital adrenal hyperplasia. Eight children, ages 4-18 yrs, will have 24-hr pharmacokinetic and pharmacodynamic profiles of cortisol, 17-hydroxyprogesterone and androstenedione concentrations while on oral hydrocortisone therapy (admission 1), during an initial trial of the subcutaneous hydrocortisone pump (admission 2), and after 6 weeks of subcutaneous hydrocortisone pump treatment (admission 3). An integrated pharmacokinetic and pharmacodynamic model will be used to determine cortisol, 17-hydroxyprogesterone and androstenedione parameters to compare the duration of time subjects have these concentrations outside acceptable ranges. Funding Source - FDA OOPD
Prospective Phenotyping of Autonomous Aldosterone Secretion
Aldosterone DisorderAdrenal Gland Disease1 moreThis prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.
Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy
Adrenal DiseaseThe purpose of this study is to compare two surgical methods of adrenalectomy. One is called PRA(posterior retroperitoneal adrenalectomy), which is performed through 3 or 4 holes at patient's back. The other is LA(laparoscopic adrenalectomy) which is performed through patient's abdominal cavity after making 3 or 4 holes in the abdomen.
Steroid Panel for One-step Diagnosis of Adrenal Diseases
Adrenal DiseaseThe aim of this study is to develop a one-step diagnostic method for adrenal diseases, Patients with adrenal diseases including non-functioning adrenal adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Using mass spectrometry analysis based on a multisteroid panel, serum, urine, saliva, and hair samples of the patients will be analyzed. The diagnostic yield of each and combination of steroids will be evaluated.
Unilateral Laparoscopic Adrenalectomy for Resistant Hypertension in Patients With Adrenal Diseases...
Resistant HypertensionAdrenal DiseaseULARH is a 2-arm, prospective, open-labeled, multi-center randomized clinical trial.The purpose of this study is to compare the effectiveness of medical treatment and unilateral laparoscopic adrenalectomy for resistant hypertension in patients diagnosed with adrenal disease based on imaging tools.Relative ratio of end-point events occurence in three years is considered as primary outcome. Furthermore, we will exploit clinical factors which could indicate a favorable outcome in participants who accepted surgical treatment in this study.
Lipid-poor Adrenal Masses: Evaluation With Chemical Shift MRI
Adrenal Gland DiseaseThe purpose of this study is to determine if certain MRI sequences can accurately diagnose adrenal masses of unknown origin.