Tiotropium / Respimat One-Year Study
Pulmonary DiseaseChronic ObstructiveTo evaluate the long term effects of treatment with two doses of Tiotropium delivered by the Respimat inhaler in patients with COPD.
A Study of UK-369,003 on the Safety and Efficacy in Patients With COPD
Pulmonary DiseaseChronic ObstructiveA randomised, controlled study investigating the effect of UK-369,003 on exercise tolerance in patients with COPD
Effect of Tiotropium Inhalation Capsules (Spiriva) on Exercise Tolerance in COPD Patients
Pulmonary DiseaseChronic ObstructiveThe objective of this trial is to determine whether tiotropium inhalation capsules (Spiriva, Bromuro de Tiotropio), compared to placebo, enhances the improvement in exercise tolerance seen in patients with chronic obstructive pulmonary disease (COPD) who participate in pulmonary rehabilitation.
Effect of Roflumilast on Pulmonary Function and Respiratory Symptoms in Patients With Chronic Obstructive...
Chronic Obstructive Pulmonary DiseaseCOPDThe aim of the study is to compare the effect of roflumilast and placebo on the lung function in patients with COPD.
Lung Health Study II
Lung DiseasesLung Diseases2 moreTo determine if participants with chronic obstructive pulmonary disease, who were assigned to inhaled corticosteroids had a lower rate of decline in lung function and lower incidence of respiratory morbidity compared to participants assigned to placebo.
Trial of Inspiratory Muscle Rest and Exercise in Chronic Obstructive Lung Disease
Lung DiseasesLung Diseases2 moreTo test the effectiveness of ventilatory muscle rest (VMR) using home negative pressure ventilation (NPV) in improving exercise performance, alleviating dyspnea, and improving the quality of life in patients with severe chronic obstructive lung disease.
National Emphysema Treatment Trial (NETT)
EmphysemaLung Diseases3 moreTo evaluate the long term efficacy, morbidity and mortality associated with medical therapy with lung volume reduction surgery (LVRS) as compared to medical therapy alone and to define patient selection criteria. The trial, conducted in conjunction with a patient registry, is supported by the NHLBI, the Centers for Medicare and Medicaid Services (CMS), and the Agency for Healthcare Research and Quality (AHRQ).
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)
EmphysemaLung Diseases3 moreTo conduct feasibility studies on the use of retinoids in the treatment of emphysema. Specific objectives are to identify optimal patient populations, retinoids, doses, dosing schedules, routes of administration, and outcome measures preparatory to conducting a larger, controlled, clinical trial on the efficacy of retinoid therapy in the management of emphysema.
Evaluation of the Effectiveness of the Self-developed Pulmonary Lobar Ventilation Detector
Chronic Obstructive Pulmonary DiseaseThe goal of observational study is to Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of the effectiveness of the self-developed pulmonary lobar ventilation detector. Participants will use the self-developed pulmonary lobar ventilation detector and the imported Chartis detection system to evaluate the target pulmonary lobar collateral ventilation.
Evaluation of Skeletal Muscle Function Using Ultrasonic Elastography
Chronic Obstructive Pulmonary DiseaseThe goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography. Participants will undergo pulmonary rehabilitation.