A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol...
Alcohol DependenceThe long-term safety and efficacy of nalmefene hydrochloride at 20 mg in patients with alcohol dependence will be evaluated in a multicenter, open-label, uncontrolled trial.
A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Alcohol DependenceSeveral lines of evidence suggest that classic hallucinogens such as psilocybin can facilitate behavior change in addictions such as alcohol dependence. The proposed investigation is a multi-site, double-blind active-controlled trial (n = 180, 90 per group) contrasting the acute and persisting effects of psilocybin to those of diphenhydramine in the context of outpatient alcoholism treatment.
EEG/Event-related Brain Potential Risk Markers as Predictors and Outcomes of SUD Treatment in Adolescents...
Alcohol Use DisorderThis study investigates the effect of a computerized approach/avoidance retraining (aka cognitive bias modification) over and above treatment as usual for patients in treatment for substance use disorders. The computerized training entails viewing pictures of drug and non-drug related stimuli, and then using the computer to make the drug pictures smaller and the non-drug pictures larger. Participants will also take part in an EEG/event-related brain potential assessment at the beginning and end of treatment to identify brain measures that are associated with treatment response.
Efficacy and Safety of High Dose Baclofen for Alcohol Dependence
AlcoholismThe proposed study will carefully test the hypothesis that a robust dose of baclofen (90 mg/day) has efficacy and is safe in individuals with alcohol dependence. Furthermore, the proposal will test whether an indicator of physical dependence, i.e. drinks/drinking day, predicts response to baclofen. Additionally, the proposal will examine the anti-anxiety effects of baclofen within an alcohol dependent population and ascertain whether baseline levels of anxiety predict response to baclofen.
Naltrexone for Individuals of East Asian Descent
Alcohol Use DisorderThis study will elucidate the pharmacogenetic effects of the Asn40Asp SNP of the OPRM1 gene on biobehavioral and neural markers of response to naltrexone in individuals of East Asian descent, an ethnic group most likely to express the positive predictive allele.
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
SchizophreniaAlcohol Use DisorderThis double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients
Alcohol DependenceThe purpose of the study is to assess the efficacy of Xylka® (baclofen) compared to placebo on continuous abstinence rate during 20 weeks of treatment, after withdrawal, in alcohol dependent patients receiving Brenda therapy sessions.
Dutasteride Treatment for the Reduction of Heavy Drinking in Men
AlcoholismAlcohol Abuse1 moreThis study will examine the safety and potential benefit of the medication dutasteride to help men reduce or stop drinking alcohol.
Eye Movement Desensitization and Reprocessing (EMDR) in Alcohol Dependent Patients
Alcohol DependenceOne interesting approach to the treatment of addiction is the use of Eye Movement Desensitization and Reprocessing (EMDR) (Shapiro, 1989). Although research on the feasibility and efficacy of EMDR on addiction is limited and often lacks methodological rigor, the results are promising and suggest that further research on this subject is warranted. This proposal consists of two studies to test and determine the acceptability, feasibility and efficacy of EMDR as an intervention to reduce craving and alcohol use in alcohol dependent outpatients as well as to gain further understanding in underlying working mechanisms.
Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders
Alcohol Use DisorderEvaluate the efficacy of CBT4CBT and clinician-delivered CBT relative to standard treatment for reducing alcohol use