Mifepristone for the Prevention of Relapses of Alcohol Drinking
Alcohol Use Disorders (AUD)The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone
Self-estimates and Objective Blood Alcohol Concentration in Emergency Department
Alcohol Use DisorderBlood Alcohol ContentMany patients presenting in Emergency Department (ED) present alcohol acute intoxication. Some previous studies in general population found that young people under- or over-estimated of blood alcohol concentration (BAC). The hypothesis of the study is that self-estimation of BAC by the patient is under-estimated. Moreover, comparing self-estimation of BAC and objective measure of BAC, which is routinely performed in ED, could increase in patients the awareness of the disorders, increase motivation to change of the patient, and increase the rates of seeking-treatment six months after the first evaluation, in particular in patients with alcohol use disorders. To the investigators knowledge, there is no study investigating self-estimation, compared to objective measurement of blood alcohol concentration in patients with alcohol intoxication presenting to an Emergency Department (ED). The study will assess blood alcohol concentration and self-estimates of BAC, using the Subjective Effects of Alcohol Scale for Measuring Subjective Response to Alcohol in 100 patients with or without alcohol use disorders according to DSM-5 classification (using MINI scale and Alcohol Use Disorders Identification Test (AUDIT)
Intensive Referral to Al-Anon: Benefits to Concerned Others and Their Drinkers
Alcohol Use DisorderThis study is examining the effectiveness of Al-Anon Intensive Referral (AIR) with Concerned Others (COs) of individuals in treatment for alcohol use disorders ("drinkers"). AIR's goal is to facilitate Al-Anon participation and positive outcomes among COs.
Role of BP1.3656 on Alcohol Responses
Alcohol Use DisorderThe current study will determine whether a novel pharmacotherapy, BP1. 3656, affects laboratory alcohol self-administration in participants with alcohol use disorder (AUD).
Understanding Genetic Risk for Alcohol Use Disorder
Alcohol Use DisorderThe purpose of this study is to evaluate an online educational tool that will help individuals better understand alcohol use disorder, risk factors, and genetic risk information and to better understand participant's beliefs regarding alcohol use disorder. This study does not involve genetic testing. Investigators will not be giving participants any personalized genetic feedback as part of the study; however, investigators will ask participants to imagine that they receive different hypothetical genetic risk scores and respond to survey items.
Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia
Effects of Family History of Alcoholism and Sex on Alcohol AnalgesiaSelf-medication of pain with alcohol is a common, yet risky, behavior. Evidence suggests family history of alcoholism may affect the degree to which alcohol use relieves pain, but the independent contributions of expectation and conditioning have not been previously studied. Interactive effects of sex and family history are also currently unclear. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.
Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects...
AlcoholismBackground: - This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system. It helps induce relaxation and sleep and balances the brain by inhibiting over-excitation. Several studies have reported that anxiety disorders such as panic attacks, seizure disorders, and numerous other conditions including addiction, are all related to low GABA activity. Therefore, we will examine differences in GABA levels between healthy controls and subjects with alcohol addiction. Studies such as this are important to the understanding of the role of GABA in alcohol addiction.
A Study of Brain Receptor Occupancy in Healthy Subjects
Alcohol DependenceTo measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.
Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
Alcohol DrinkingCigarette Smoking ToxicityThe proposed research will investigate whether smokers with vs. without current at-risk alcohol drinking (ARD) respond to reduced nicotine cigarettes by increasing their alcohol consumption or smoke exposure, thereby diminishing the hypothesized public health benefit of these new products.
Medication Development in Alcoholism: Acamprosate Versus Naltrexone
AlcoholismThe purpose of this study is to develop and validate a human laboratory model for prediction of medication efficacy in clinical trials for relapse prevention in alcohol dependence.