Optimizing Pharmacotherapy for Bipolar Alcoholics
Bipolar DisorderAlcohol DependenceThe purpose of this study is to test the efficacy of naltrexone and valproate in the treatment of comorbid bipolar disorder and alcohol dependence.
A Randomized Clinical Trial of Alcohol Care Management
Alcohol DependenceA randomized study of Alcohol Care Management for the treatment of alcohol dependence in primary care settings.
Sertraline Pharmacotherapy for Alcoholism Subtypes
AlcoholismThe purpose of this study is to determine whether Sertraline, compared to placebo, is effective in the treatment of alcohol dependence as a function of the subtype of alcoholic patient being treated. This involved administering sertraline (to a maximum of 200 mg/day) or an inactive placebo for a 14-week treatment period.
Study To Examine Effect Of CP-866,087 On Consumption And Craving Of Alcohol In Alcohol Dependent...
AlcoholismTest the hypothesis that increasing doses of CP-866,087 will decrease the total number of drinks consumed during a 2 hour acute alcohol consumption assessment and to determine the safety and tolerability of multiple doses of CP-866,087 in alcohol dependent subjects compared to placebo.
Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)
AlcoholismThis study will compare the effectiveness of ondansetron (Zofran) and naltrexone (ReVia) both alone and in combination in treating Early Onset Alcoholics versus Late Onset Alcoholics. All subjects will received standardized Cognitive Behavioral Therapy. Followup assessments will be completed at 1, 3, 6, and 9 months after treatment.
Naltrexone, Craving, and Drinking
AlcoholismThis 5-week study will examine the effects of naltrexone on alcohol craving, drinking rates, and reaction to drinking-related triggers, or cues, in participants' everyday environment and in laboratory sessions. Participants will monitor and record their daily desires to drink, environmental circumstances in which urges occur, and drinking behavior using a palm top computer. Participants will receive naltrexone or a placebo. One week after receiving medication, all participants will be asked to respond to alcohol-related cues that may or may not arouse the desire to drink.
Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)
AlcoholismSmokingThe purpose of this study is to determine the effectiveness of naltrexone (Revia) or matched placebo combined with nicotine patch (Nicotrol) or placebo patch using a 2x2 design in reducing drinking and smoking in patients with both nicotine and alcohol dependence.
Naltrexone Treatment for Alcoholic Women
AlcoholismEating DisorderThis study will assess naltrexone's effectiveness in treating alcoholism in women and provide information on its potential value in treating eating disorders common among alcoholic women. Alcoholic women with and without both eating disorders and depression will be randomly assigned to placebo or naltrexone treatment. Each group will receive behavioral therapy for 12 weeks, with followup 6 months after treatment.
Pharmacologic Relapse Prevention for Alcoholic Smokers
AlcoholismSmokingThis study will compare the long-term use of bupropion (Wellbutrin) and placebo for reducing the rate of smoking relapse in recovering alcoholics who achieved initial abstinence from smoking with nicotine patch therapy. The study will also determine the cessation rate in the 8th week of treatment among recovering alcoholics using a nicotine patch. The patch dose is projected to serve as a 100-percent replacement.
Disulfiram for Cocaine-Alcohol Abuse - 3
Alcohol-Related DisordersCocaine-Related DisordersThe purpose of this study is to evaluate disulfiram for cocaine-alcohol abuse.