Treatment Engagement With Technology-assisted Treatment
AlcoholismSubstance-related Disorders2 moreThis research is being done to study whether using an Internet-based program, called the Therapeutic Education System (TES), would be helpful for the treatment of substance use and other psychiatric problems.
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
Alcohol DependenceBipolar Disorder3 moreThe study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their usual mood stabilizing medications relative to subjects treated with placebo plus usual mood stabilizing medications over a 16 week period.
Duloxetine Versus Pregabalin for Alcohol Dependence
Alcohol DependenceA 12-week, double-blind, placebo-controlled parallel group study will be conducted with 150 outpatients with alcohol dependence, with random assignment to pregabalin 300 mg/d, duloxetine 40 mg/d, or placebo in conjunction with manual-guided behavioral counseling and follow-up visits 1 week and 3 months post-treatment.
Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial...
Alcohol DependenceThis study would like to test whether the combination of ondansetron and olanzapine will be superior to placebo at decreasing self-reported heavy drinking among early onset alcoholics.
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism...
Major Depressive DisorderAlcohol Abuse1 moreThis is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will improve outcomes for this population.
Disseminating Organizational SBI Services at Trauma Centers
Alcohol AbuseAlcohol DependenceThe goal of the Disseminating Organizational Screening and Brief Interventions Services (DO-SBIS) investigation is to capitalize on the unique opportunity afforded by the American College of Surgeons' mandate by taking early steps to insure high quality, evidence-based SBI services are implemented and outcomes are assessed. In the first phase of the investigation, SBI services will be assessed for all 190 level I trauma centers in the United States. In the second phase of the investigation, 20 level I trauma centers will be selected for randomization to intervention or control conditions.
Combination Nicotine Replacement for Alcoholic Smokers
SmokingAlcoholismThe overall objective of the study is to develop recommendations for treatment programs to help alcoholic smokers to stop smoking. A sample of 175 alcohol dependent cigarette smokers will be recruited from the community and treated in a 6-month outpatient alcohol and tobacco treatment program. The 175 patients will be divided into two groups. One group will receive an active nicotine patch and active nicotine gum. The other group will receive an active nicotine patch and placebo nicotine gum. Followup assessments will be conducted for 1-year from the beginning of treatment.
Outpatient Treatment of Alcohol Withdrawal Syndrome
AlcoholismAlcohol WithdrawalThe purpose of this study is to compare a fixed-schedule therapy versus a symptom-triggered therapy for alcohol withdrawal syndrome in medical outpatients. Objectives: Self-governance in monitoring AWS (alcohol withdrawal syndrome) symptoms and medication Clinically controlled trial of two regimens for medical treatment of alcohol withdrawal syndrome Outpatient treatment of alcohol withdrawal syndrome
Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
AlcoholismAlcohol Dependence1 moreThis study will evaluate naltrexone and cognitive-behavioral therapy treatments for alcohol dependence and post-traumatic stress disorder (PTSD). Subjects will be randomly assigned a 6-month treatment of either: 1) naltrexone alone, 2) naltrexone with PTSD psychosocial therapy, 3) a placebo with PTSD psychosocial therapy, or 4) placebo alone. An enhanced medication management intervention will accompany all treatment conditions. Follow-up assessments will be completed at 9 and 12 months after treatment.
Bupropion as a Smoking Cessation Aid in Alcoholics
AlcoholismSmokingThe purpose of this study is to test the use of time-released bupropion (Wellbutrin) in patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking. Patients will receive either a time-released bupropion or placebo. Both groups will receive nicotine replacement therapy during the 9 week study. A final followup assessment will be conducted 6 months from the start of treatment.