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Active clinical trials for "Hypersensitivity"

Results 1721-1730 of 1774

Retrospective Study of Immediate Hypersensitivity (IHS) Reactions to Platinum Salts in the University...

Drug Allergy

To assess the efficacy of skin tests with platinum salts in patients suspects with immediate hypersensitivity reactions. All patients adressed in consultation to the Allergy Department of university hospital of nancy for an immediate hypersensitivity reaction to platinum salts between 2015 and 2021 were retrospectively recruited.

Unknown status3 enrollment criteria

Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality

Myocardial InfarctionMyocardial Injury

The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin. With advancing technology this test has become more sensitive and is now called a high sensitivity troponin. This is a very effective way of rapidly excluding a heart attack if the test is negative. However there are a number of causes of a raised high sensitivity other than a heart attack, particularly critical illness states. In the absence of features of a heart attack an abnormal result therefore suggests that the heart is inflamed or unwell causing the release of high sensitivity troponin. The DIGNITY study will examine the consequences of high sensitivity troponin elevation in patients in intensive care and assess whether it has a role as a biomarker for predicting outcome.

Unknown status4 enrollment criteria

Assessment and Prediction of Cetuximab-Induced Hypersensitivity Reactions Using Cetuximab Specific...

Tumor Disease Including Colorectal CancerHead & Neck Squamous Cell Carcinoma

Background Cetuximab (trade name Erbitux) is a murine-human chimeric monoclonal antibody to human epidermal growth factor receptor (EGFR). This drug has been used as a treatment for colorectal cancer and head and neck cancer. It is known that allergic reactions can occur in more than 5% of the patients, although the side effects are relatively low compared with other chemotherapeutic agents. It is known that cetuximab can induce hypersensitivity even at the first administration, unlike other anticancer drugs. In this study, we aimed to establish a model to predict patients with hypersensitivity reaction before administration of cetuximab and to provide safe chemotherapy. Recruitment method and consent procedure The study is designed for analysis patients scheduled for administration of cetuximab for the first time. Patients matching the selection and exclusion criteria with voluntary agreement to the study will be enrolled. Enrolled patients will be tested for skin prick test and serum sIgE before cetuximab administration.

Unknown status5 enrollment criteria

High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery

Acute Myocardial InfarctionDisorder; Heart5 more

A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples. Those biomarkers are used to diagnose an acute myocardial infarction. Postoperative myocardial infarction (MI) is a frequent and important complication after cardiac surgery with high morbidity and mortality. Therefore it is very important to recognize any cardiac event in patients who undergo cardiac surgery. Different diagnostic tools can be used to the diagnosis of acute myocardial infarction; however few is known about the value of high-sensitivity cardiac troponin T (hs-cTn) to diagnose a MI after heart valvular surgery. The aim of this study is to determine the upper reference limit of high-sensitivity troponin T concentration to consider the diagnosis of acute myocardial infarction in patients undergoing heart valvular surgery.

Unknown status7 enrollment criteria

The Effects of Primary Pterygium on Contrast Sensitivity Preoperatively and Postoperatively

Primary Pterygium

Pterygium is the growth of conjunctival tissue onto the cornea, usually from the nasal quadrant of the cornea.Visual acuity may be reduced due to direct invasion of the visual axis or astigmatism induced by the pterygium. Contrast sensitivity measures two variables, size, and contrast which could comprehensively reflect the visual quality of the primary pterygium patients. In this study, we would investigate the the effects of primary pterygium on contrast sensitivity preoperatively and on the 1st, 3rd and 6th month postoperatively, moreover, the related parameters on the contrast sensitivity in the primary pterygium patients would be analyzed.

Unknown status8 enrollment criteria

Regulation of Blood Dendritic Cells During Immune Therapy for Hymenoptera Venom Allergy

Hymenoptera Venom Allergy

Dendritic cells (DC) play a key role in the pathogenesis of allergic diseases. The regulation of blood dendritic cells in patients with hymenoptera venom allergy before and during immune therapy is unknown.

Unknown status5 enrollment criteria

The Effect of Exercise on Pain Sensitivity in a Population With Ongoing Neck Pain Compared to Healthy...

Neck PainHealthy

This study investigates the effect of exercise on pain sensitivity in ongoing neck pain patients compared to a healthy control group.

Unknown status24 enrollment criteria

Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein...

Acute Pancreatitis

Acute pancreatitis (AP) is a potentially life-threatening disease with varying severity of presentation. Nearly 60%-80% of all cases of AP in developed countries are attributable to either gallstone disease or alcohol abuse. The incidence is similar in both sexes, although alcohol abuse is the more common cause in men and gallstones is the more common cause in women.

Unknown status4 enrollment criteria

Penicillin Allergy in Shfayim Clinic

Penicillin Allergy

revising penicillin allergy in the medical records, by taking full medical history and giving a challange test, in order to imrove the medical records and treatment possibilities.

Unknown status2 enrollment criteria

Impact of E-learning on Parental Confidence in Managing Food Allergy

Food Allergy in ChildrenFood Allergy in Infants

Education and dietary support are integral in managing food allergy in children. The study aim is to analyze the impact of E-learning on parental confidence in managing their child's food allergy.

Unknown status3 enrollment criteria
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