search

Active clinical trials for "Amyloidosis"

Results 401-410 of 487

Carpal Tunnel/Amyloidosis Blood Sample Study

Carpal Tunnel SyndromeAmyloidosis

Carpal tunnel is an early manifestation of amyloidosis in a significant minority of patients. This specimen collection protocol will allow the investigators to screen patients with carpal tunnel syndrome for amyloidosis.

Completed6 enrollment criteria

A Diagnostic Screening Trial Seeking AL Amyloidosis Very Early

Plasma Cell DyscrasiaMonoclonal Gammopathy

This protocol seeks to enroll smoldering multiple myeloma (SMM) and monoclonal gammopathy of undetermined significant (MGUS) patients with λ light chain (LC) involvement, a group of patients for whom standard of care is observation not treatment. Patients with SMM and MGUS have a precursor plasma cell disorder from which light chain amyloidosis (AL) can evolve. In this trial, enrolled subjects will have blood and if available bone marrow cells evaluated by molecular testing to determine their clonal λ LC variable region (VL) germline gene. Seventy percent of AL cases involve just 7 germline donors, 5 of which are λ germline donors. The hypothesis that will be tested with this protocol is that the presence of AL germline genes associated with AL in patients with a pre-existing diagnosis of λ SMM or λ MGUS indicates the presence of AL or risk of progression to AL.

Completed2 enrollment criteria

Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological...

Amyloid-beta

The purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (CSF) through modulation of the sleep-wake cycle.

Completed34 enrollment criteria

Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage

Intracerebral Hemorrhage

To evaluate Pet AV-45 Amyloid imaging in the etiological diagnosis of primary non traumatic intracerebral hemorrhage (Cerebral Amyloid Angiopathy and hypertension related hemorrhage).We hypothesize that patients with lobar hemorrhage (probably related to Cerebral Amyloid Angiopathy) will have a greater AV45 cortical binding than patients with deep hemorrhage (probably related to hypertension).

Completed11 enrollment criteria

Long-term Outcomes of Patients With Primary Amyloidosis After Stem Cell Transplantation

Amyloidosis

This study examines the value of stem cell transplantation in managing light chain amyloidisis.

Completed3 enrollment criteria

Vyndaqel Drug Use Investigation (Regulatory Post Marketing Commitment Plan)

Transthyretin Familial Amyloid Poluneuropathy

The purpose of this study is to understand safety (e.g., occurrence of adverse drug reactions [ADRs]) and efficacy data on the long-term use of Vyndaqel Capsules (hereinafter referred to as Vyndaqel) in all patients who received this drug under actual use conditions after its marketing.

Completed2 enrollment criteria

Carpal Tunnel Syndrome and Amyloid Cardiomyopathy

AmyloidosisCardiomyopathy3 more

The investigators will prospectively evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid in the soft tissue that is removed. Patients who have tissue that stains positive for amyloid will undergo cardiac testing to look for evidence of cardiac involvement.

Completed7 enrollment criteria

A Study to Investigate the Relationship Between Duration of Treatment and Response in Patients With...

Multiple MyelomaImmunoglobulin Light-chain Amyloidosis

The study will provide information on outcomes in people with multiple myeloma, or systemic AL amyloidosis, or both, under standard care. AL is short for amyloid light-chain. Standard care means the participant will be treated according to their clinic's standard practice. The study sponsor will not be involved in how participants are treated but will provide instructions on how the clinics will record what happens during the study. The aim of the study is to learn if treatment duration makes a difference in how participants with multiple myeloma or systemic AL amyloidosis respond to their treatment. During the study, participants will be treated according to their clinic's standard practice. Participants must have started their treatment up to 12 months before taking part in this study. During the study, the participants will visit their clinic every 3 months. These are extra visits to their clinic's standard visits.

Completed25 enrollment criteria

Evaluating the Efficacy of Artificial Intelligence-based Computer Aided Diagnosis Software That...

Alzheimer DiseaseMild Cognitive Impairment

Purpose of clinical trial; This clinical trial is designed to evaluate the effectiveness of 'NeuroAI' prediction accuracy compared to the amyloid PET test results by retrospectively collecting medical data of patients with mild cognitive impairment to evaluate the effectiveness of artificial intelligence-based brain image detection and diagnosis assistance software 'NeuroAI'. Participants; Patient with mild cognitive impairment

Completed15 enrollment criteria

MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA...

Cerebral Amyloid AngiopathyIntracerebral Hemorrhage

In this three-year proposal, we will explore the MRI-visible EPVS in CAA and investigate its pathophysiology using animal models. Our specific aims include: (1) Establish the relationship of MRI-visible enlarged perivascular space and CAA, (2) Determine whether vascular amyloid clearance in CAA is associated with lymphatic drainage system, (3) Establish longitudinal data for MRI-visible enlarged perivascular space and cerebral amyloid angiopathy progression.

Unknown status10 enrollment criteria
1...404142...49

Need Help? Contact our team!


We'll reach out to this number within 24 hrs