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Active clinical trials for "Amyotrophic Lateral Sclerosis"

Results 681-690 of 757

F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS)

The purpose of this research study is to evaluate tau distribution in the brain of subjects with: ALS caused by different genetic mutations, any mutation carriers (with or without symptoms), any non-mutation carrier, any sporadic FTD, normal controls.

Completed11 enrollment criteria

Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurological disease. Nonspecific symptoms lead to a delay in the diagnosis, only confirmed by the electrophysiologic study. Objectives. To establish the diagnostic value of ultrasonography in ALS. To evaluate the rate of muscle and nerve degeneration by ultrasonography in patients with ALS. To check the relationship between ultrasound, clinical variables and functional tests in patients with ALS. Methods. A longitudinal observational study in a consecutive sample of patients diagnosed with ALS will be realized. All the patients will be examined 3 times during 6 months and capabilities associated with ALS and muscle strength will be assessed. Bilateral and cross sectional ultrasonography of several muscles and also median and tibial nerves will be performed. All the images will be processed and analyzed for obtaining morphometric variables (muscle thickness and nerve area) and textural ones (echogenic variation, entropy, homogeneity, textural contrast and correlation). Frequency of twitches will be also recorded. After longitudinal study, a survival study will be performed in relation to functional and sonographic variables.

Completed3 enrollment criteria

Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS

C9ORF72 Amyotrophic Lateral Sclerosis (ALS)

This research study is being performed to better understand a specific form of Amyotrophic Lateral Sclerosis (ALS) caused by a mutation (or abnormality) of the C9ORF72 gene. This mutation is the most common genetic cause of ALS, and is present in 40% of ALS patients with a family history of ALS and 5-10% of ALS patients without a family history of ALS.

Completed8 enrollment criteria

Monitoring of Non-invasive Ventilation During Sleep in ALS

Amyotrophic Lateral Sclerosis

Non-invasive ventilation (NIV) has already shown to improve survival and quality of life in patients with amyotrophic lateral sclerosis (ALS). Quality of sleep seems already to be impaired in patients with preserved diaphragmatic dysfunction. Until now, only few research has been performed on the quality of sleep in patients with ALS when using NIV, and these data are mainly based on patient reported outcomes.Further on, only very little research has been done on patient-ventilator interaction. Our study would like to perform research on quality of sleep before and after NIV use by using full polysomnography with incorporation of transcutaneous carbon dioxide measurement and built-in ventilator software.

Completed6 enrollment criteria

Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate

Amyotrophic Lateral Sclerosis

There is a lack of prospective and population-based epidemiological data on amyotrophic lateral sclerosis in Germany so far. The purpose of this registry is to investigate the incidence, course and phenotypic variety of ALS in Rhineland-Palatinate, a South-West German state of about 4 million inhabitants.

Completed5 enrollment criteria

Longitudinal Study of Outcomes Measures in ALS Trials

Amyotrophic Lateral Sclerosis

A new strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure static limb strength in patients with ALS. The investigators will compare ATLIS data with data from two commonly used ALS outcomes measures, the ALS Functional Rating Scale-Revised (ALSFRS-R) and slow vital capacity (SVC) in a prospective, longitudinal study. All three outcomes measures will be performed on 100 subjects collected preferably at bi-monthly clinic visits during the study period.

Completed4 enrollment criteria

Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study...

Prostate CancerRenal Cancer2 more

This is a parallel group, single institution, prospective clinical study. The purpose of this study is to assess whether the Jawbone Up 24, a consumer based accelerometer, can be a feasible tool to study physical activity in cancer patients and patients with Amyotrophic Lateral Sclerosis (ALS).

Completed25 enrollment criteria

Expanded Access Protocol: Repeated Administration of Nurown® (Autologous MSC-NTF Cells) for the...

Amyotrophic Lateral Sclerosis

Expanded Access for treatment with investigational product MSC-NTF cells(NurOwn®) for participants who completed all scheduled treatments and follow-up assessments in the BCT-002-US study

No longer available12 enrollment criteria

Investigation on Home Care Needs of ALS Patients and Their Caregivers

Amyotrophic Lateral Sclerosis

The research target To investigate the home nursing knowledge needs of ALS patients; Investigate the needs of ALS caregivers for home nursing knowledge; To compare the differences between patients and caregivers in the knowledge needs of patients' refusal to care, so as to provide patients and caregivers with targeted care, meet the needs of patients, improve the quality of life of patients, and extend the survival period.

Completed2 enrollment criteria

Italian Validation of the Beaumont Behavioural Inventory (BBI)

Amyotrophic Lateral Sclerosis

Up to 50% of patients affected with amyotrophic lateral sclerosis (ALS) can show behavioral dysfunctions within the spectrum of frontotemporal degenerations (FTD) - namely, apathy, disinhibition, loss of sympathy/empathy, perseverative and stereotyped behaviours, dietary changes [Strong et al., 2017]. The Beaumont Behavioural Inventory (BBI) [Elamin et al., 2017] is a questionnaire designed for detecting FTD-spectrum behavioural changes in ALS patients. The present study aims at both validating the BBI in an Italian ALS population and determining normative cut-off values of the instrument.

Completed2 enrollment criteria
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