Hepcidin and Glucose Metabolism
Iron Deficiency Anemia of PregnancyIron Metabolism Disorders2 moreGestational diabetes mellitus (GDM), defined as hyperglycemia with blood glucose values above normal but below those diagnostic of DM, and iron deficiency (ID) with or without anemia (IDA) are common during pregnancy. Both disease patterns are associated with an increased risk of complications during pregnancy and at delivery and may have a variety of negative effects on different aspects of child development. Thus, GDM and ID/IDA during pregnancy should be prevented. Whether iron supplementation with high oral doses acutely increases hepcidin during pregnancy, and whether this acute iron-induced increase in hepcidin decreases insulin sensitivity, is uncertain.
Defining a Dosing Regimen With Maximal Absorption for Oral Iron Supplementation During Pregnancy...
Iron Deficiency Anemia of PregnancyIron deficiency anemia (IDA) is common during pregnancy and has adverse effects on the mother, fetus and newborn. Oral iron supplements are usually recommended to prevent ID/IDA during pregnancy. The aim of this study is to define an iron supplementation schedule with maximal absorption using serum hepcidin profiles and stable iron isotopes in pregnant women. In this randomized, open-label trial, fractional and total iron absorption will be compared from daily dosing with 60 mg iron versus alternate day and every third day dosing with 120 mg iron in pregnant Thai women with low iron stores (n=28) during their second trimester of pregnancy. This study could have wide impact, providing the evidence base for revised, improved recommendations for iron supplementation during pregnancy.
Improvement of Fatigue Symptoms in the Iron Deficiency Anemia With Iron Succinylate Therapy
AnemiaIron-deficiency2 moreThe treatment of anemia depends on its cause. Patients with underlying iron-deficient anemia should be treated or referred to a specialist (eg gynecologist, gastroenterologist) for treatment.deficiency anemia are global health problems and common medical conditions seen in everyday clinical practice. Iron is vital for biological functions, such as breathing, energy production, DNA synthesis, and cell proliferation. Iron deficiency refers to the reduction of iron stores and precedes the occurrence of iron deficiency anemia. Iron deficiency anemia is a more severe condition in which low levels of iron are associated with anemia and the presence of small cellular red blood cells.
Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions
Iron Deficiency AnemiaThis study aims to examine the relation between iron status and maternal-child interactions as well as maternal depressive symptoms in mothers from central Pennsylvania.
Registry Study of ID & IDA in Korean Patients With Heart Failure
Iron Deficiency AnemiaThe prevalence of Iron Deficiency and Iron Deficiency Anemia in Korean HF patient
Iron Deficiency Anaemia in Pregnant Patients Presenting for Antenatal Care
Iron Deficiency Anemia of PregnancyThis is a cross-sectional, prospective study of iron deficiency anaemia among pregnant patients presenting for antenatal care at a secondary level institution in the Western Cape, Mowbray Maternity Hospital, over a one-week period.
Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and...
AnaemiaSchistosomiasis Infection2 moreThe purpose of this study is to determine the extend and the nature of anemia in school children and the correlation between anemia and schistosomiasis infections, malaria infections and/or malnutrition (iron deficiency).
Intravenous Iron May Increase Depression Among Hemodialysis Patients
DepressionHemodialysis Complication1 morethe aim of this study is to assess whether increased ferritin after intravenous iron therapy will lead to increased prevalence of major depression among treated patients.
Non-invasive Diagnostics of Iron Deficiency in Surgical Patients by Measuring Zinc Protoporphyrin-IX...
Iron-deficiencyAnemia1 moreIn approx. 40% of the incidences anemia is caused by iron deficiency (= ID). In turn, preoperative iron-deficiency anemia (= IDA) is associated with an increase in morbidity and mortality as well as with the need for a blood transfusion. A successful preoperative treatment of IDA via iron supplementation requires a timely screening of iron deficiency, typically done by analyzing specific blood parameters. This however of course requires drawing a blood sample which further reduces the patients' blood volume and is in many cases stated as an inconvenient procedure. Measured in blood zinc protoporphyrin-IX (= ZnPP) is an established parameter to detect ID. This study aims to evaluate a prototype device detecting ZnPP non-invasively in the intact oral mucosa of surgical patients. Results from the non-invasive measurement will be compared to reference measurements of ZnPP from residual blood samples (HPLC analysis) as well as to other parameters including Hb level and iron profile (MCH [= mean corpuscular hemoglobin], MCV [= mean corpuscular volume], ferritin, transferrin, transferrin saturation, soluble transferrin receptor, CRP).
Diagnostic of Iron Deficiency by Means of Non Invasive Measurement of Zink Protoporphyrin IX
Iron-deficiencyZnPP is being build in the case of a functional iron deficiency. Zinc instead of iron is implemented into protoporphyrin IX. This ZincProtoporphyrin (ZnPP) can be detected non invasively. Non invasive and invasive optical measurement of ZnPP will be compared. Additionally ZnPP measurements will be compared to other iron deficiency parameters for validation by the investigators.