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Active clinical trials for "Angina Pectoris"

Results 31-40 of 454

The Improving ATTENDance to Cardiac Rehabilitation Trial

Myocardial InfarctionHeart Failure4 more

The benefits of cardiac rehabilitation are well known. However, despite center based cardiac rehabilitation (CBCR) representing guideline-based care for patients with cardiovascular disease, most patients do not complete the maximum number of sessions allowed by third party insurance payers. As such, many patients may not be receiving the full clinical benefit ascribed to CR. This study will assess the efficacy of an innovative approach to CR delivery on attendance by combining both center-based and remote- or home-based CR sessions. The intervention group combines center-based CR and remote-/home-based CR and is tailored to the individual needs of each patient, accomplished with the assistance of an easy-to-access telecommunications methodology (telemedicine)

Active16 enrollment criteria

Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial

Microvascular AnginaAngina Pectoris5 more

Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected. Recent advances in quantifying myocardial blood flow using stress perfusion cardiac magnetic resonance imaging (CMR) has potential for accurate detection coronary microvascular dysfunction. The CorCMR diagnostic study involves stress perfusion CMR in patients with suspected INOCA to clarify the prevalence of subgroups of patients with underlying problems, such as microvascular disease or undisclosed obstructive coronary artery disease, that might explain their anginal symptoms. A nested, prospective, randomised, controlled, double-blind trial will determine whether stratified medical therapy guided by the results of the stress perfusion CMR improves symptoms, well-being, cardiovascular risk and health and economic outcomes.

Recruiting10 enrollment criteria

The OCT SORT-OUT VIII Study

Coronary Artery DiseaseAngina Pectoris1 more

The purpose of this study is to compare early vessel healing after implantation of SYNERGY drug eluting stent (DES) or BioMatrix NeoFlex DES at one and three months in two cohorts.

Active15 enrollment criteria

Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study...

Coronary Artery DiseaseStable Angina3 more

The purpose of this study is to assess whether the use of physiology parameters as guidance post-percutaneous coronary interventions (PCI) is associated with less risks of target vessel failure (TVF) and angina-related events than standard angiographic guidance.

Recruiting7 enrollment criteria

Atherosclerotic Lesion Proteomics by Harvesting Angioplasty Balloons (ALPHA).

AnginaStable5 more

The purpose of the study is to identify proteins, metabolites and signal pathways related directly to symptomatic atherosclerosis and to disease progression. In the study, we use residual material from angioplasty catheter balloons and from vascular surgery plus blood samples. It is the hypothesis that material left on the catheter balloons used for angioplasty can be used for proteomics and metabolomics evaluation that will identify inflammation-associated proteins and signaling pathways directly in the diseased vessel. The tissue samples will be collected after the procedure and blood samples will be collected at the procedure plus after 6-12 months. The tissue and blood samples will be analyzed using mass spectrometry methods and a standard panel of biomarkers will also be analyzed using standardized methods. The analyses will include study of inflammation-associated peptides observed in autoinflammation as well as thrombogenic signaling pathways and local expression of biomarkers. The analyses of proteins, metabolites and/or biomarkers will be compared between cases (stable angina, unstable angina/non-STEMI, STEMI and vascular surgery) and controls (procedures not related to coronary artery diseases) to identify molecular processes related directly to symptomatic atherosclerosis and will be associated with disease progression using data from medical journals and National Health registries. The study will recruit 225 patients from Rigshospitalet University Hospital, Copenhagen, and Herlev-Gentofte Hospital.

Recruiting4 enrollment criteria

Physiology and Residual Ischemia After Percutaneous Coronary Intervention

Ischemic Heart DiseaseAngina Pectoris3 more

Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure. EASY-PRIPCI is an observational study evaluating the incidence of abnormal physiology results in patients undergoing repeat angiography after uncomplicated percutaneous intervention (PCI).

Recruiting5 enrollment criteria

Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population

Acute Myocardial InfarctionNon-Obstructive Coronary Atherosclerosis3 more

The MINOCA-GR registry will be the first nationwide study aiming to obtain data regarding prevalence, demographics, clinical profile, previous anginal status, presence of cardiovascular risk factors, management and outcomes in patients with Myocardial Infarction with Non-Obstructive Coronary Arteries. An additional purpose of the registry is to highlight, for the first time worldwide to the best of the investigator's knowledge, the role of cardiac computed tomography angiography for risk stratification and personalized therapeutic approach in MINOCA patients.

Recruiting13 enrollment criteria

Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina...

Refractory Angina PectorisRefractory Angina

REGENERATE-COBRA will examine whether autologous stem cell treatment can improve angina symptoms and quality of life for patients with refractory angina. Patients will be randomised (randomly allocated with a 50:50 chance) to either the 'treatment' or the 'sham' group - they will not know which group they are in. In the 'treatment' group: Stem cells will be collected from bone marrow in the patient's hip under local anaesthetic (a bone marrow aspiration). Under local anaesthetic, the stem cells will be infused into the arteries that supply blood to the heart through a small tube inserted either in the wrist or the groin. The follow-up involves a phone call at 1 month and 12 months and clinic visit at 6 months. In the 'sham' group: A sham bone marrow aspiration is performed - a 3mm nick in the skin will be made under local anaesthetic. A sham cell infusion is performed - a small tube is inserted either in the wrist or groin under local anaesthetic. The follow-up involves a phone call at 1 month and 12 months and clinic visit at 6 months.

Not yet recruiting29 enrollment criteria

SIROOP Registry - A Prospective Registry Study to Evaluate the Outcomes of Coronary Artery Disease...

Coronary DiseaseCoronary Artery Disease10 more

The purpose of the SIROOP Registry is to retrospectively and prospectively collect baseline, clinical and procedural characteristics of patients who have undergone PCI and are treated with either currently available sirolimus or paclitaxel coated DCBs (see Table 1), irrespective of clinical presentation as well as to prospectively collect data about their clinical outcomes. Outcomes will be compared in different clinical subgroups. The impact of current DCBs in different clinical settings and coronary artery lesions on cardiovascular outcomes will be assessed.

Recruiting8 enrollment criteria

Safety and Clinical Performance of the DREAMS 3G Resorbable Magnesium Scaffold System

Coronary Artery DiseaseAtherosclerosis5 more

The objective of this study is to assess the safety and efficacy of the DREAMS 3G in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to a contemporary drug eluting stent (DES).

Not yet recruiting47 enrollment criteria
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