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Active clinical trials for "Spondylitis, Ankylosing"

Results 201-210 of 409

Prevention of Arthritis-Related Work Disability

Rheumatoid ArthritisSystemic Lupus Erythematosus3 more

People with rheumatic disorders (arthritis) often have trouble keeping their jobs. This study will look at whether vocational rehabilitation (VR) will improve the ability of employed people with arthritis to keep their jobs. Job retention VR services target key factors that increase the risk of job loss. They aim to modify jobs to reduce barriers caused by functional limitations and disease symptoms, future career planning, and establish a partnership with a VR counselor for ongoing help. We will conduct the study among patients with rheumatic disorders recruited in eastern Massachusetts. We will give 120 study participants job retention services provided by VR counselors. We will give another 120 participants literature about employment- related resources. We will compare the outcomes of the two groups to evaluate the usefulness of job retention services in preventing job loss in people with rheumatic disorders.

Completed5 enrollment criteria

Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis...

Ankylosing Spondylitis

The primary objective of this study is to evaluate the effect of filgotinib versus placebo on signs and symptoms of active ankylosing spondylitis (AS), evaluated by Assessment of SpondyloArthritis international Society 40% improvement (ASAS40) response at Week 16 in participants with active AS who are naive to biologic disease-modifying antirheumatic drug therapy.

Withdrawn23 enrollment criteria

Prediction of Treatment Response at 6 Months by Combinatorial Analysis of Serum Biomarkers in Biotherapy...

SpondylitisAnkylosing

The main objective of this trial is to search for biomarkers associated with the success of adalimumab treatment in order to generate an algorithm to predict the response to this treatment at 6 months in spondyloarthritis and to define its metrological properties on this cohort. The algorithm will allow to better target patients who will have an important benefit/risk ratio for adalimumab treatment.

Completed17 enrollment criteria

Study of Ixekizumab in Participants With Active Ankylosing Spondylitis (AS)

SpondylitisAnkylosing

This study will assess the safety and efficacy of ixekizumab (LY2439821) compared to placebo in participants with active AS.

Withdrawn16 enrollment criteria

Prediction of the Answer to the Treatment by Biotherapies for Naive Spondyloarthritis by Combinatorial...

SpondylitisAnkylosing

The aim of this trial is the caracterisation of a predicting algorithm of the answering response for patients with etanercept treatment in spondyloarthritis disease. This algorithm will help to target patients patients who have a risk / benefit important for etanercept treatment.

Completed18 enrollment criteria

Infliximab and Methotrexate in Ankylosing Spondylitis

Ankylosing Spondylitis

There is a great individual variability of pharmacokinetic of infliximab in patients treated for ankylosing spondylitis (AS). Moreover, some patients have a treatment with methotrexate (MTX), others have not. Thus, the aim of this study is to assess the effect of MTX on the pharmacokinetic properties of infliximab in 30 patients treated for AS, 15 with MTX, 15 without.

Completed3 enrollment criteria

Role of LILRA3 in Ankylosing Spondylitis and Axial Psoriatic Patients

Autoimmune Diseases

To evaluate the frequency of LILRA3 in Ankylosing spondylitis and Axial psoriatic arthritis patients. To investigate the association of LILRA3 with Ankylosing spondylitis and Axial psoriatic arthritis disease activity and severity.

Not yet recruiting3 enrollment criteria

bIosimilar of aDalimumab, an European evAluation

Rheumatoid ArthritisAnkylosing Spondylitis3 more

The study objective is aimed to describe all country, site, investigator and patient variables that lead to treatment persistence for at least 12 months among patients with rheumatologic and intestinal chronic inflammatory diseases who were switched to FK adalimumab, in order to develop a model to predict persistence at 12 months.

Not yet recruiting9 enrollment criteria

Multi-omics Database for Integrative Microbiome Analysis in a Cohort of Korean Patients With Ankylosing...

Ankylosing Spondylitis

Multicenter Human Derivatives Prospective Cohort Study: Clinical information will be collected from patients with ankylosing spondylitis and their families who have provided research consent. And clinical samples including blood, saliva, feces, and mucosal biopsy tissue (from patients scheduled for sigmoid colonoscopy or routine colonoscopy examinations) will be collected. Multi-omics data production and laboratory analysis will be conducted using the collected samples, followed by integrated bioinformatic analysis using the produced data."

Not yet recruiting21 enrollment criteria

Chinese Spondyloarthritis Inception Cohort (CESPIC)

Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)Non-radiographic Axial Spondyloarthritis (Nr-axSpA)5 more

The Chinese Spondyloarthritis Inception cohort (CESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in China on patients with early SpA including ankylosing spondylitis (AS, also known as radiographic axial spondyloarthritis) and non-radiographic axial SpA. The objectives of CESPIC are to learn about the course of SpA during the very early stage of the disease, to appropriately assess the outcome including radiographic progression of patients after several years of follow-up, to identify outcome predictors, to assess quality of life, function, and costs (direct and indirect costs). CESPIC has been recently expanded to recruit patients with other forms of SpA / conditions associated with SpA: reactive arthritis, acute anterior uveitis, Crohn's disease as well as with psoriasis / axial psoriatic arthritis.

Not yet recruiting2 enrollment criteria
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