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Active clinical trials for "Aortic Valve Insufficiency"

Results 41-50 of 119

Evaluation of Effectiveness and Safety of Evolut R Valve In Patients With Pure Aortic Regurgitation...

Aortic ValveAortic Valve Insufficiency4 more

This study is to evaluate the efficacy and safety of transcatheter aortic valve replacement (TAVR) in severe 'pure Aortic regurgitation (AR)' using Evolut R valve (Medtronic, Minneapolis, MN).

Terminated23 enrollment criteria

Perceval S Aortic Heart Valve Study- North America

Aortic Valve StenosisAortic Valve Stenosis With Insufficiency3 more

To demonstrate the safety and effectiveness of the Perceval S heart valve when used to replace a diseased or dysfunctional aortic valve or aortic valve prosthesis.

Terminated21 enrollment criteria

Mitroflow DL Post Approval Study- North America

Aortic StenosisAortic Regurgitation8 more

Prospective, non-randomized, multicenter post-approval study to collect long term clinical and echographic data on Mitroflow DL patients.

Terminated11 enrollment criteria

The CardioPAT Project: A Randomized Trial

Coronary Artery DiseaseAortic Stenosis3 more

The purpose of this study is to determine whether intra- and postoperative use of the cardioPAT® cell saver decreases the need for allogenic red blood cell transfusion in patients, who undergo open heart surgery (with cardiopulmonary bypass) and preoperatively have an increased risk for bleeding.

Terminated10 enrollment criteria

Edwards SAPIEN-3 Periprosthetic Leakage Evaluation Versus Medtronic CoreValve in Transfemoral Aortic...

Periprosthetic Aortic Valve Regurgitation After TAVI

Transcatheter aortic valve replacement (TAVR) is a good alternative treatment for patients with severe aortic valve stenosis with similar mid-term success rates as compared to surgery. Periprosthetic aortic regurgitation (PAR) after TAVR remains an important limitation of this technique. Moderate to severe PAR occurs in 15-45% of the cases and it is an independent predictor of mortality after TAVR. Little is known about potential differences in severity of PAR among different types of aortic valve prosthesis. The current randomized study aims to evaluate potential differences between the Edwards SAPIEN bioprosthesis and the Medtronic CoreValve® system with main focus on PAR and additional focus on other clinical and imaging endpoints. Primary objective of this study is to investigate the difference in the severity of PAR, measured with 3-dimensional transesophageal echocardiography (3DTEE), between patients undergoing the implantation of the Edwards SAPIEN bioprosthesis versus patients receiving the Medtronic CoreValve® bioprosthesis. Secondary objectives of this study include: investigating the value of different imaging modalities in evaluating periprosthetic regurgitation after TAVR and studying the difference in clinical endpoints according to VARC-2 definitions and quality of life after TAVR between two available aortic valve prostheses.

Terminated6 enrollment criteria

Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients...

Aortic StenosisAortic Regurgitation3 more

To compare changes in Left Ventricular Mass (LVM) depending on each blood pressure regulation between the intensive care group and the usual care group for patients with hypertension accompanied by aortic valve disease and evaluate an influence of blood pressure regulation on improvement of left ventricular hypertrophy and its safety

Completed31 enrollment criteria

HAART 200 Aortic Valve Annuloplasty Trial

Aortic Insufficiency

The HAART 200 "Aortic Annuloplasty during Bicuspid Aortic Valve Reconstruction" Trial is a prospective, non-randomized, multi-center trial to evaluate the safety and effectiveness of the HAART 200 bicuspid annuloplasty ring when used to surgically stabilize the aortic valve annulus in patients undergoing repair of bicuspid aortic valves (BAV) for predominant aortic insufficiency (AI).

Completed38 enrollment criteria

Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000

Aortic Valve DisorderAortic Valve Insufficiency3 more

The purpose of this observational trial is to gather further clinical data to confirm the safety and performance of the Edwards Pericardial Aortic Bioprosthesis, Model 11000 in this trial population.

Completed11 enrollment criteria

Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic...

Aortic Valve Insufficiency

The primary objective of this study is to evaluate the effect of beta-blocker on left ventricular (LV) remodeling in asymptomatic patients with moderate to severe aortic regurgitation.

Completed4 enrollment criteria

HAART Model 300 Annuloplasty Ring

Aortic Regurgitation

This investigation is a prospective, non-randomized, multi-center trial to evaluate the safety and effectiveness of the HAART model 300 annuloplasty ring when used to surgically repair a leaking aortic valve using a 3-D intra-annular mounting frame

Completed41 enrollment criteria
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