search

Active clinical trials for "Aphasia, Primary Progressive"

Results 101-110 of 231

Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral...

ALSFTD

This is an OLE study conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and clinical effects of WVE-004 in adult patients with ALS, FTD, or mixed ALS/FTD phenotype with a documented mutation in the C9orf72 gene. To participate in the study, patients must have successfully completed Phase 1b/2a WVE-004-001 study.

Terminated3 enrollment criteria

Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's...

Alzheimer's DiseaseBehavioral Variant Frontotemporal Dementia

The purpose of this study is to provide subjects who have completed participation in a Phase 2 or Phase 3 trial of LMTM continued access to therapy and to evaluate the long-term safety of LMTM.

Terminated11 enrollment criteria

Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency...

Acid Sphingomyelinase DeficiencyNiemann-Pick Disease

The purpose of this study is to determine the safe range of single doses of rhASM administered to adults with ASM deficiency.

Terminated12 enrollment criteria

BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES

Primary TauopathiesCorticobasal Degeneration Syndrome6 more

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different Primary Tauopathy Syndromes

Terminated50 enrollment criteria

Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia

Primary Progressive Nonfluent Aphasia

Nonfluent/agrammatic variant primary progressive aphasia (nf/avPPA) is a fatal neurodegenerative disease that begins with isolated language deficits. There is currently no cure or treatment for this disease. Repetitive Transcranial Magnetic Stimulation (rTMS), a noninvasive neuromodulatory technique, is effective in major depression, and studied in many other conditions including nf/avPPA. Here the investigators propose to study the feasibility and change in language and brain function of a newer rTMS protocol (intermittent theta-burst stimulation, iTBS) using a randomized, blinded crossover design: participants will receive active or sham iTBS for two weeks and then switch groups without them or clinicians knowing their group. The investigators hypothesize that brain function and performance with language tasks will change after active iTBS.

Terminated17 enrollment criteria

Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders

PSPCBD10 more

The investigators aim to learn more about symptoms suggestive of a neurodegenerative process.

Enrolling by invitation7 enrollment criteria

Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China

Amyotrophic Lateral SclerosisFrontotemporal Dementia1 more

To investigate the biomarkers of MND/FTD spectrum disease To explore the possible pathogenesis of MND/FTD

Enrolling by invitation10 enrollment criteria

Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular...

Amyotrophic Lateral SclerosisFrontotemporal Dementia9 more

The investigators laboratory has been studying families with a history of ALS for more than 30 years and is continuing to use new ways to understand how genes may play a role in ALS, motor neuron disease and other neuromuscular disorders. The purpose of this study is to identify additional genes that may cause or put a person at risk for either familial ALS (meaning 2 or more people in a family who have had ALS), sporadic ALS, or other forms of motor neuron disease in the hopes of improving diagnosis and treatment. As new genes are found that may be linked to ALS in families or individuals, the investigators can then further study how that gene may be contributing to the disease by studying it down to the protein and molecular level. This includes all forms of ALS, motor neuron disease and ALS with fronto-temporal dementia(ALS/FTD). We also continue to study other forms of neuromuscular disease such as Miyoshi myopathy, FSH dystrophy and other forms of muscular dystrophy by looking at the genes that may be associated with them. There have been a number of genes identified that are associated with both familial and sporadic ALS, with the SOD1, C9orf72, and FUS genes explaining the majority of the cases. However, for about 25% of families with FALS, the gene(s) are still unknown. The investigators also will continue to work with families already identified to carry one of the known genes associated with ALS.

Enrolling by invitation4 enrollment criteria

Voices Of Individuals: Challenges and Experiences Of bvFTD

Frontotemporal DementiaFrontotemporal Degeneration3 more

The VOICE Of bvFTD study is a telephone interview research study about life with or at risk for behavioral variant frontotemporal dementia (bvFTD). The study aims to understand how bvFTD impacts individuals' day to day lives, how people think about themselves, and what challenges they face.

Enrolling by invitation9 enrollment criteria

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Amyotrophic Lateral SclerosisFrontotemporal Dementia4 more

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Enrolling by invitation6 enrollment criteria
1...101112...24

Need Help? Contact our team!


We'll reach out to this number within 24 hrs