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Active clinical trials for "Sleep Apnea Syndromes"

Results 131-140 of 2072

The Effect of OSA on Brain Waste Clearance

Obstructive Sleep ApneaDementia1 more

Recent ground-breaking research has shown that clearance of toxic neuro-metabolites from the brain including the proteins β-Amyloid (Aβ) and tau that form dementia causing plaques and tangles is markedly impaired when sleep is disturbed. This suggests that dementia risk may be increased in people with sleep disorders such as obstructive sleep apnea (OSA). Longitudinal studies have linked OSA with a 70-85% increased risk for mild cognitive impairment and dementia. Despite this strong link, little is known about the OSA-specific mechanistic underpinnings. It is not fully understood as to how sleep disturbance in OSA inhibit brain glymphatic clearance. However, it is known that OSA inhibits slow wave sleep, profoundly activates sympathetic activity, and elevates blood pressure - particularly during sleep. These disturbances have, in turn, been shown to independently inhibit glymphatic function. Previous studies have attempted to sample human cerebrospinal fluid (CSF) involved in glymphatic clearance for dementia biomarkers during sleep. However, these studies were severely limited by the need for invasive CSF sampling. To address this problem, a set of newly available, highly sensitive blood based SIMOA assays will be used to study glymphatic function in people treated for severe OSA who undergo CPAP withdrawal. Furthermore, novel methods will be utilized to capture changes in slow wave sleep, blood pressure and brain blood flow together with sleep-wake changes in blood levels of excreted neuro-metabolites to define the pathophysiological mechanisms that inhibit brain cleaning in OSA.

Recruiting20 enrollment criteria

Impact of Tele-visit on Patients Continous Positive Airway Pressure (CPAP) Follow-up by Home Care...

Obstructive Sleep Apnea

To determine the impact of telecare on continous positive airway pressure (CPAP) patients follow up by home care provider (HCP)

Recruiting7 enrollment criteria

Sleep Disordered Breathing With Opioid Use

Sleep ApneaOpioid Use1 more

There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.

Recruiting17 enrollment criteria

Use of Intraoral Suction and Its Effects on Obstructive Sleep Apnea

Obstructive Sleep Apnea of Adult

To learn whether stabilization of the tongue using intraoral suction is tolerable and what effects this approach has on sleep parameters in obstructive sleep apnea.

Recruiting15 enrollment criteria

Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

Obstructive Sleep Apnea

Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. The Investigators propose a study examining the physiologic effect of ansa cervicalis stimulation (ACS) alone and in combination with HNS during PSG and DISE.

Recruiting7 enrollment criteria

A Mindfulness-Based Intervention to Improve CPAP

Obstructive Sleep Apnea (Moderate to Severe)Obstructive Sleep Apnea

The main purpose of this study is to assess the effectiveness of a mindfulness-based intervention in improving CPAP use compared to online peer support

Recruiting8 enrollment criteria

A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal...

Sleep Apnea

The main aim is to see if danavorexton can help improve people's breathing in the recovery room after abdominal surgery.

Recruiting16 enrollment criteria

Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal...

Sleep ApneaPost Menopausal1 more

One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH). There are clear-cut signs of OS in postmenopausal women that may be further enhanced by SA. In rats exposed to IH, an estradiol receptor alpha agonist decreases the level of OS markers. The aims of this study are to compare OS in apneic and non-apneic postmenopausal women and to demonstrate that OS will improve after 3 months of treatment with ER alpha agonists (Duavive) in apneic post-menopausal women.

Recruiting13 enrollment criteria

Multimodal Remote Monitoring and Integrated Educational Program in OSA Patients Initiating Continuous...

Obstructive Sleep Apnea Syndrome

Continuous positive airway pressure (CPAP) is the first line therapy for Obstructive Sleep Apnea Syndrome (OSAS) but has limited impact for reducing cardio-metabolic risk. Combined treatment strategies including physical activity and weight loss management have emerged in association with CPAP. Patient's engagement might be supported by connected devices and smartphone applications measuring physical activity, blood pressure, weight and sleep duration. Data fusion of these parameters with CPAP-remote telemonitoring will allow personalized coaching and integrated care of OSAS with cardio-metabolic co-morbidities.

Recruiting24 enrollment criteria

The Impact of Interscalene Block on Sleep Disordered Breathing

Sleep Disordered BreathingObstructive Sleep Apnea

This is a randomized controlled trial evaluating the impact of interscalene block on worsening of upper airway collapse in sleep disordered breathing for patients undergoing ambulatory shoulder surgery.

Recruiting9 enrollment criteria
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