Relationship of YWHAH Polymorphisms to Rheumatoid Arthritis Disease Severity
Rheumatoid ArthritisIt is hypothesized that one or several of these 6 single nucleotide polymorphisms (SNPs) (rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, and rs933226) in the YWHAH gene could be related to RA disease severity.
Occupational Performance Problems in Individuals With Rheumatoid Arthritis
RheumatoId ArthritisAim: To identify the main occupational performance problems reported by individuals with rheumatoid arthritis and the relationship between these activities with work status of participants . Methods: the investigators conducted a cross-sectional study with 81 patients with RA. Individuals were interviewed the Canadian Occupational Performance Measure. Data was described in frequencies and percentages, and the Pearson's chi-square test was used to determine the asymptotic association between the occupational performance problems with work.
Ultrasound Evaluation of Remission in Rheumatoid Arthritis
Rheumatoid Arthritis Patient With Remission :Ultrasonographic Disease ActivityEvaluate correlations between the validated 12 joints-Naredo ultrasound score (B-mode (0-3), PD (0-3) or PDUS (0-3, max between B-mode or PD)) and the DAS28-ESR, DAS28-CRP, CDAI, SDAI and ACR-EULAR criteria for remission in routine care.
Immunoregulatory Mechanisms of Treg Cells Induced by Tocilizumab
Arthritis,RheumatoidWe can speculate that the best responders to tocilizumab should have multiple related elements (Treg CD39, adenosine, IL-35) successfully induced and expressed in order to play its beneficial role. The study of these elements and its pathways could help identify the best responders to tocilizumab treatment.
Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in...
ArthritisRheumatoidRheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.
A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid...
Rheumatoid ArthritisThis six months non-interventional, observational, post-marketing, multi-center and local study will evaluate the differences in the use of corticosteroids between RA participants receiving TCZ or a TNF-inhibitor, in participants who have discontinued the use of a TNF-inhibitor as their first biological treatment.
Longterm Followup of Patients With Rheumatoid Arthritis Treated With Methotrexate
External Causes of Morbidity and MortalityLongterm followup of patients with rheumatoid arthritis 30 years after starting a baseline treatment with Methotrexate.
Evaluation of the Intestinal Microbiota and Bacterial Translocation in Patients With Rheumatoid...
ArthritisRheumatoidThe main objective of this study is to compare the intestinal microbiota in newly diagnosed rheumatoid arthritis (RA) with that from individuals without RA. The first analysis will compare the proportion of filamentous bacteria in the intestinal microbiota between the two groups.
Genetics and Mechanisms of Rheumatoid Arthritis
Rheumatoid ArthritisLeukocytes2 moreThe study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.
Activity Limitations in Rheumatoid Arthritis
Rheumatoid ArthritisObjective: To evaluate what factors contribute to activity limitations in subjects with rheumatoid arthritis considering the International Classification of Functioning, Disability and Health model. Methods: A cross-sectional study on 81 individuals with rheumatoid arthritis (RA) using instruments to measure five constructs of the component activities.