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Active clinical trials for "Respiratory Aspiration"

Results 21-30 of 809

The Effect of Inhaled Corticosteroids on Vocal Fold Nodules in Children

Vocal Fold Nodules

Voice disorders are the most common communication disorder across the lifespan and vocal fold nodules are the most frequent pathology affecting voice in children. The goal of the present study is to determine the safety and feasibility of a short-course of inhaled corticosteroids in addition to standard voice therapy for treating vocal fold nodules.

Recruiting7 enrollment criteria

Impact of Inhaled PT003 on Complexity and Variability of Tidal Breathing and Oscillatory Mechanics...

Copd

Prospective, single-arm, open label, multicentre, phase II pilot study to evaluate the immediate and short term (one month) impact of a new long acting double bronchodilator on innovative parameters in stable and moderate to severe COPD patients. Variability and complexity of resting tidal breathing Oscillatory resistance and reactance of airways Tidal volume variability and complexity is decreased in airway obstruction and is expected to improve with a bronchodilator treatment, together with lung mechanics. The relationship with changes in dyspnea and conventional pulmonary function tests is the second aim of study. After baseline assessment of these parameters, clinical and lung function evaluation will be performed 2 hours post-drug (peak drug effects). Patients will continue treatment with PT003 for 4 weeks. On Day 30, the same clinical and lung function assessments will be performed pre (trough) and 2h-post dose in order to obtain after-treatment measurements.

Recruiting7 enrollment criteria

Nasal Obstruction Compared by Rhinomanometry and Nasal Inspiratory Peak Flow After Endoscopic Nasal...

Pituitary Adenoma InvasiveNasal Obstruction

The aim of the project is to determine whether nasal inspiratory peak flow is sufficient for preoperative and postoperative measurement of nasal patency compared to rhinomanometry.

Recruiting6 enrollment criteria

An Open Label Trial Evaluating Tacrolimus Inhalation Powder in Adult Lung Transplant Recipients...

Lung Transplant Rejection

This is an open label, multicenter, safety and PK study comparing safety, efficacy, and pharmacokinetic (PK) levels of Tacrolimus Inhalation Powder in lung transplant patients that require reduced tacrolimus blood levels due to kidney toxicity. Part A of the study will consist of a 12 week safety, efficacy, and PK study. Part B of the study will be an optional safety extension following successful completion of the 12 week safety, efficacy, and PK study. Patients would have the option to continue Tacrolimus Inhalation Powder for up to 1 year, with a possibility to extend to 2 years depending on the results from Part A.

Recruiting25 enrollment criteria

Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With...

Obstructive Pulmonary FunctionRestrictive Pulmonary Function

The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in adult subjects with obstructive or restrictive pulmonary function. In the first treatment period, subjects will be randomized to receive either a single dose (100 mg) of I-ASA powder via a Dry Powder Inhaler (DPI) OR a single dose (162 mg) of C-ASA tablets. After a washout period, subjects will be crossed over to receive the other treatment in the second treatment period. All subjects will receive both treatments during the study. Each single dose treatment will be followed by up to 24 hours of serial post-dose PK, PD, and safety/tolerability assessments.

Recruiting41 enrollment criteria

Dental Appliance to Treat SDB in Children

SnoringApnea3 more

The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.

Recruiting13 enrollment criteria

The Effect of Post-Surgery Exercise in Patients With Total Knee Replacement Surgery

Total Knee ReplacementBreathing Tecniques

postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today. Many researchers in the literature have reported that approximately 50-70% of patients receive inadequate pain treatment after surgery, and many patients complain of moderate or severe pain. Poor control of postoperative pain may cause deep venous thrombosis and delayed wound healing, increased hospital stay, and delayed return to daily life activities. This may negatively affect the quality of life and recovery of patients Therefore, there is a need for methods that increase pain control, such as non-pharmacological methods, to accelerate postoperative recovery. Nurses in postoperative pain management; they help control pain with non-pharmacological methods such as breathing exercises, positioning, relaxation techniques, massage, listening to music, hot application, cold application, and distraction.

Recruiting7 enrollment criteria

Radiotherapy Delivery in Deep Inspiration for Pediatric Patients

Pediatric Cancer

TEDDI is a non-randomised phase II trial in Scandinavia. All pediatric patients, referred for radiotherapy in the thorax or abdomen and irrespective of diagnosis, are eligible. Deep inspiration breath-hold (DIBH) is a simple radiotherapy technique, which could have a dramatic impact on the risk of late effects in children. In DIBH, the radiotherapy is delivered while the patient holds his/her breath (4-6 sequential breath-holds). The anatomy is changed and imaging artifacts from respiratory movement are diminished. DIBH is widely used in adult patients with breast cancer and mediastinal lymphoma to minimize the risk of radiation-induced late effects due to a reduced dose to the healthy organs. Also, the technique is simple and cost-efficient. For pediatric patients, the investigators aim to: Estimate the dosimetric benefit of radiotherapy using DIBH compared to free-breathing Establish the compliance of DIBH Determine if DIBH is an accurate and reproducible strategy Optimize treatment planning considering the risk from loss of tumour control as well as the risk of late effects.

Recruiting8 enrollment criteria

Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment

Sleep Disordered BreathingAble Bodied

Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.

Recruiting10 enrollment criteria

Comparative Effects of ACBT and Diaphragmatic Breathing on Pulmonary Function and Sputum Diary After...

Breathing Exercises

To compare the effects of active cycle of breathing technique and diaphragmatic breathing on pulmonary functions and sputum diary after coronary artery bypass graf

Recruiting9 enrollment criteria
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