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Active clinical trials for "Astrocytoma"

Results 341-350 of 370

Radiomics for Prediction of Survival in GBM

GlioblastomaGlioma1 more

Radiomics, the extraction of large amounts of quantitative image features to convert medical images into minable data, is an in-development field that intends to provide accurate risk stratification of oncologic patients. Published prognostic scores only take clinical variables into account. The investigators hypothesize that a combination of CT/MRI features, molecular biology and clinical data can provide an accurate prediction of medical outcome. The long term objective is to build a Decision Support System based on the predictive models established in this study.

Completed5 enrollment criteria

Multicenter Safety Trial Assessing an Innovative Tumor Molecular and Cellular Print Medical Device...

Glioma : Oligodendroglioma or Astrocytoma

The purpose of the study is to determine the clinical safety and operability of the innovative tissue imprint device ProTool.

Unknown status25 enrollment criteria

Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor...

Adult Diffuse AstrocytomaAdult Mixed Glioma5 more

This trial studies the natural history of brain function, quality of life, and seizure control in patients with brain tumor who have undergone surgery. Learning about brain function, quality of life, and seizure control in patients with brain tumor who have undergone surgery may help doctors learn more about the disease and find better methods of treatment and on-going care.

Completed19 enrollment criteria

Temozolomide All-Case-Registered Surveillance (Designated Drug Use Investigation)(Study P05062)...

GliomaAstrocytoma

The purpose of this study is to confirm the safety and efficacy of temozolomide in patients with newly diagnosed malignant glioma (concomitant with radiotherapy and then as monotherapy) and relapsed malignant glioma (as monotherapy) when used in the daily medical practices. Post-marketing surveys are not considered applicable clinical trials and thus the results of this survey will not be posted at its conclusion. The results will be submitted to public health officials as required by applicable national and international laws.

Completed3 enrollment criteria

Neural Basis of Language Processing

OligoastrocytomaAstrocytoma1 more

According to the O.M.S. Classification, grade 2 glioma is a pre-cancerous lesion, slowly progressive, infiltrating the central nervous system, mainly affecting young adults. This surgery should nevertheless be conducted in awake condition to achieve two conflicting goals: get maximum brain tissue infiltrated by the tumor while preserving the integrity of functional structures. So awake after opening the skull, the patient undergoes a series of preoperative tests, administered by a speech therapist present in the operating room. This procedure allows the neurosurgeon to establish an individual functional brain mapping in real time, through the observation by the SLP of the patient's answers to direct electrical stimulation applied to the cortical and sub-cortical. This support is based on the extraordinary plasticity demonstrated by the brain in the presence of a slowly progressive lesion. To ensure the patient the highest achievable load should increase our understanding of brain function, including the neural bases of language, glioma grade 2 is predominantly localized functional area of language.

Completed4 enrollment criteria

Clinical Development of MR Spectroscopy and Imaging in Brain Cancers

Malignant GliomasAstrocytomas1 more

The Investigators will examine the disease specificity of 2-hydroxyglutarate in non-glioma brain lesions, and the clinical utility of 2-hydroxyglutarate, glycine and citrate in isocitrate dehydrogenase (IDH) mutated gliomas and IDH wild type gliomas.

Completed30 enrollment criteria

Study of Blood Samples and Risk of Infection in Patients With Newly Diagnosed Malignant Supratentorial...

Brain and Central Nervous System TumorsInfection

RATIONALE: Gathering information over time from laboratory tests of patients with newly diagnosed malignant supratentorial astrocytoma may help doctors learn more about the effect of treatment on white blood cell count and the risk of infection. PURPOSE: This clinical trial is studying blood samples and risk of infection in patients with newly diagnosed malignant supratentorial astrocytoma.

Completed28 enrollment criteria

Immunophenotyping From Blood of Patients With Malignant Gliomas

Anaplastic AstrocytomaGlioblastoma Multiforme

In this explorative study immunological changes during tumor therapy will be analyzed in patients with malignant glioma. Immunophenotyping before and during therapy is used as analysis method. Thereby immune cells are quantitatively and qualitatively detected from patient's blood at continuous time points. Additionally relevant mediators like cytokines, danger signals and chemokines are analyzed by other methods. Obtained results may give information about the effects of therapy on immunological processes and immune cells and may help to find immunological based predictive or prognostic tumor markers and to define time points for including additional immune therapy in the future.

Completed8 enrollment criteria

Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2)

GlioblastomaGlioma1 more

The purpose of this surveillance is to evaluate the postmarketing safety and efficacy of Temodal capsule (temozolomide) under actual conditions of use, and to understand some of the following points that are in question and doubt: Incidence of adverse events under actual conditions of use (Serious and Nonserious Adverse Events); Adverse Drug Reactions not shown in the directions for use (will be stated as Unexpected Adverse Reaction); Adverse Event caused by misuse, abuse, or drug interactions; Other information concerned with safety or efficacy.

Completed4 enrollment criteria

Biomarkers for Tuberous Sclerosis Complex (BioTuScCom)

Hypomelanotic MaculesFacial Angiofibroma7 more

International, multicenter, observational, longitudinal study to identify biomarker/s for Tuberous Sclerosis Complex and to explore the clinical robustness, specificity, and long´-term variability of these biomarker/s

Terminated6 enrollment criteria
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